CD74 antibodies, human

CD74 antibodies, human

Clone: REA1103 | Dilution: 1:50
Clone REA1103 recognizes CD74, a non-polymorphic type II integral membrane protein. CD74 is also known as MHC class II–associated invariant chain and exists in multiple isoforms in human ranging from 33 to 43 kDa in size. Initially known for its role as the MHC II chaperone, CD74 primary function is suggested to regulate the MHC class II molecules folding and intracellular sorting. CD74 is also shown to form complexes with CD182 (CXCR2) and CD184 (CXCR4). A direct role of CD74 in the maturation of follicular B cells and accumulation of marginal zone B cells has also been suggested. CD74 was further shown to be one of the host molecules utilized by
H. pylori
to successfully attach to the gastric epithelial cells. Expression of CD74 is found on B cells, dendritic cells, epithelial cells, subsets of activated T cells, and low level expression is found on monocytes and macrophages.
Additional information: Clone REA1103 displays negligible binding to Fc receptors.

Alternative names

DHLAG, HLADG, II, Ia-GAMMA

Technical specifications

  • Antigen: CD74
  • Clone: REA1103
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: DHLAG, HLADG, II, Ia-GAMMA
  • Entrez Gene ID: 972
  • Molecular mass of antigen [kDa]: 33
  • Distribution of antigen: B cells, dendritic cells, epithelial cells, macrophages, monocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Leng, L. et al. (2003) MIF signal transduction initiated by binding to CD74. J. Exp. Med. 197: 1467-1476
    2. Beswick, E. J. and Reyes, V. E. (2009) CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract. World J Gastroenterol. 15(23): 2855-2861
Product options: 16
130-119-203

CD74-PE, human

for 30
tests
(1)
AUD 119.00
130-119-026

CD74-PE, human

for 100
tests
(1)
AUD 319.00
130-119-204

CD74-APC, human

for 30
tests
(1)
AUD 157.00
130-119-027

CD74-APC, human

for 100
tests
(1)
AUD 347.00
for 30
tests
(1)
AUD 157.00
for 100
tests
(1)
AUD 347.00
for 30
tests
(1)
AUD 157.00
for 100
tests
(1)
AUD 347.00
for 30
tests
(1)
AUD 138.00
for 100
tests
(1)
AUD 334.00
for 30
tests
(1)
AUD 138.00
for 100
tests
(1)
AUD 334.00
for 30
tests
(1)
AUD 215.00
for 100
tests
(1)
AUD 434.00
for 30
tests
(1)
AUD 92.00
for 100
tests
(1)
AUD 271.00