CD70 antibodies, human

CD70 antibodies, human

Clone: REA292 | Dilution: 1:50
Clone REA292 recognizes the human CD70 antigen, a 50 kDa type II transmembrane glycoprotein also known as CD27 ligand (CD27L) or tumor necrosis factor ligand superfamily member 7 (TNFSF7). CD70 is a member of the TNF superfamily and is expressed by activated mouse T, B, and NK lymphocytes, activated plasmacytoid dendritic cells (pDCs), chronic B cell lymphocytic leukemia, and large B cell lymphomas. It interacts with CD27, its ligand on T cells, in order to promote T-B cell cross-stimulation and co-stimulates B cell proliferation and immunoglobulin production. It also plays a role in the pDC-induced B cell differentiation.
Additional information: Clone REA292 displays negligible binding to Fc receptors.

Alternative names

CD27L, CD27LG, TNFSF7

Technical specifications

  • Antigen: CD70
  • Clone: REA292
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD27L, CD27LG, TNFSF7
  • Entrez Gene ID: 970
  • Molecular mass of antigen [kDa]: 21
  • Distribution of antigen: T cells, B cells, NK cells, dendritic cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Bowman, M. R. et al. (1994) The cloning of CD70 and its identification as the ligand for CD27. J. Immunol. 152(4): 1756-1761
    2. Goodwin, R. G. et al. (1993) Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. Cell 73(3): 447-456
Product options: 2
130-122-973

CD70-PE, human

for 30
tests
(1)
AUD 165.00
130-122-929

CD70-PE, human

for 100
tests
(1)
AUD 308.00

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