CD7 antibodies, human

CD7 antibodies, human

Clone: CD7-6B7 | Dilution: 1:50
Clone CD7-6B7 recognizes the human CD7 antigen, a single-pass type I membrane protein also known as leu-9 or GP40. CD7 appears early in T cell ontogeny and is expressed by most T cells in the periphery. It is also found on natural killer (NK) cells, hematopoietic progenitors, monocytes, acute lymphocytic leukemia, and some acute myeloid leukemia cells. Although the ligand is yet not identified, CD7 has been recognized as a costimulatory molecule. CD7 activates phosphatidylinositol 3-kinase which is involved in CD7-mediated regulation of integrin adhesiveness. Furthermore, it has been reported that the β-galactoside-binding lectin galectin-1 binds CD7, leading to induction of apoptosis of thymocytes and T cells, with implications for certain autoimmune diseases and T cell lymphomas.

Alternative names

GP40, Leu-9, TP41, Tp40

Technical specifications

  • Antigen: CD7
  • Clone: CD7-6B7
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: GP40, Leu-9, TP41, Tp40
  • Entrez Gene ID: 924
  • Molecular mass of antigen [kDa]: 23
  • Distribution of antigen: T cells, NK cells, monocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC-Vio770, PE, APC, Biotin, VioBright FITC
  • Selected references

    1. Gallacher, L. et al. (2000)
      Isolation and characterization of human CD34
      Lin
      and CD34
      +
      Lin
      hematopoietic stem cells using cell surface markers AC133 and CD7.
      Blood 95(ARVO Annual Meeting Abstract): 2813-2820
    2. Aruffo, A. et al. (1987) Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system. EMBO J. 6(11): 3313-3316
    3. Kobayashi, S. et al. (2013) The CD3 versus CD7 plot in multicolor flow cytometry reflects progression of disease stage in patients infected with HTLV-I. PLoS One 8(1): e53728
Product options: 10
for 30
tests
(1)
AUD 140.00
for 100
tests
(1)
AUD 340.00
130-123-308

CD7-PE, human

for 30
tests
(1)
AUD 165.00
130-123-247

CD7-PE, human

for 100
tests
(1)
AUD 308.00
130-123-326

CD7-APC, human

for 30
tests
(1)
AUD 165.00
130-123-265

CD7-APC, human

for 100
tests
(1)
AUD 354.00
for 30
tests
(1)
AUD 138.00
for 100
tests
(1)
AUD 259.00
for 30
tests
(1)
AUD 184.00
for 100
tests
(1)
AUD 336.00

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