CD57 antibodies, human

CD57 antibodies, human

Clone: REA769 | Dilution: 1:50
Clone REA769 recognizes the human CD57 antigen. CD57, also known as HNK-1 or Leu-7, is an antigenic oligosaccharide moiety detected on extracellular proteins of certain cell types. In blood, CD57 is found on 15–20% of mononuclear cells, including subsets of NK and T cells, though not on erythrocytes, monocytes, granulocytes, or platelets. Also, CD57 expression can be found on a variety of neural cell types. CD57 has been shown to be expressed on late stage effector CD8
+
T cells. The frequency of CD57
+
T lymphocytes is raised in a variety of diseases. CD57 expression is also increased on chronically activated CD8
+
T cells in persistent viral infections, such as HIV.
Additional information: Clone REA769 displays negligible binding to Fc receptors.

Alternative names

B3GAT1, GLCATP, GLCUATP, HNK-1, Leu-7, NK-1

Technical specifications

  • Antigen: CD57
  • Clone: REA769
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: B3GAT1, GLCATP, GLCUATP, HNK-1, Leu-7, NK-1
  • Entrez Gene ID: 27087
  • Molecular mass of antigen [kDa]: 38
  • Distribution of antigen: B cells, brain, CNS cells, NK cells, ES and iPS cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, APC-Vio770
  • Selected references

    1. Mechtersheimer, G. et al. (1991) Expression of the natural killer cell-associated antigens CD56 and CD57 in human neural and striated muscle cells and in their tumors. Cancer Res. 51: 1300-1307
    2. Dupuy d'Angeac, A. et al. (1993)
      Increased percentage of CD3
      +
      , CD57
      +
      lymphocytes in patients with rheumatoid arthritis. Correlation with duration of disease.
      Arthritis Rheum. 36: 608-612
    3. Ong, E. et al. (2002)
      Biosynthesis of HNK-1 glycans on O-linked oligosaccharides attached to the neural cell adhesion molecule (NCAM): the requirement for core 2 β1,6-
      N
      -acetylglucosaminyltransferase and the muscle-specific domain in NCAM.
      J. Biol. Chem. 277: 18182-18190
    4. Brenchley, J. M. et al. (2003)
      Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8
      +
      T cells.
      Blood 101: 2711-2720
    5. Palmer, B. E. et al. (2005)
      Functional and phenotypic characterization of CD57
      +
      CD4
      +
      T cells and their association with HIV-1-induced T cell dysfunction.
      J. Immunol. 175: 8415-8423
Product options: 10
130-111-963

CD57-PE, human

for 30
tests
(1)
AUD 126.00
130-111-810

CD57-PE, human

for 100
tests
(1)
AUD 334.00
130-111-964

CD57-APC, human

for 30
tests
(1)
AUD 165.00
130-111-811

CD57-APC, human

for 100
tests
(1)
AUD 365.00
for 30
tests
(1)
AUD 165.00
for 100
tests
(1)
AUD 365.00
for 30
tests
(1)
AUD 165.00
for 100
tests
(1)
AUD 365.00
for 30
tests
(1)
AUD 146.00
for 100
tests
(1)
AUD 348.00

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