CD49d antibodies, mouse

CD49d antibodies, mouse

Clone: REA807 | Dilution: 1:50
Clone REA807 recognizes the mouse CD49d antigen, a 150 kDa integrin family member, also known as integrin α4 chain. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cell-matrix interaction. CD49d associates non-covalently with the integrin ß or ß1 (CD29) forming the complex VLA4, which is expressed on peripheral lymphocytes, thymocytes, eosinophils, basophils, mast cells, dendritic cells, and monocytes. VLA4 plays a critical role in adhesion and migration of cells into tissues by binding to its ligand VCAM-1 (CD106). Together with the ß7 integrin, CD49d forms the heterodimer LPAM-1, which is a ligand for the mucosal vascular addressin (MAdCAM-1).
Additional information: Clone REA807 displays negligible binding to Fc receptors.

Alternative names

ITGA4, Itga4B, VLA-4α, Integrin alpha-4

Technical specifications

  • Antigen: CD49d
  • Clone: REA807
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: ITGA4, Itga4B, VLA-4α, Integrin alpha-4
  • Entrez Gene ID: 16401
  • Molecular mass of antigen [kDa]: 111
  • Distribution of antigen: B cells, basophils, cardiac muscle, dendritic cells, eosinophils, Langerhans cells, lymphocytes, macrophages, mast cells, monocytes, myeloid cells, NK cells, placenta, red blood cells, skeletal muscle, smooth muscle, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, VioBright 515, Biotin
  • Selected references

    1. Berlin, C. et al. (1993) Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 74(1): 185-195
    2. Fogler, W. E. et al. (1996) NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J. Immunol. 156(12): 4707-4714
Product options: 10
130-111-977

CD49d-PE, mouse

30 µg in 200 µL (1)
AUD 70.00
130-111-824

CD49d-PE, mouse

150 µg in 1 mL (1)
AUD 268.00
130-111-978

CD49d-APC, mouse

30 µg in 200 µL (1)
AUD 101.00
130-111-825

CD49d-APC, mouse

150 µg in 1 mL (1)
AUD 307.00
30 µg in 200 µL (1)
AUD 124.00
150 µg in 1 mL (1)
AUD 325.00
30 µg in 200 µL (1)
AUD 128.00
150 µg in 1 mL (1)
AUD 457.00
30 µg in 200 µL (1)
AUD 39.00
150 µg in 1 mL (1)
AUD 173.00

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