CD40 antibodies, human

CD40 antibodies, human

Clone: REA733 | Dilution: 1:50
Clone REA733 recognizes the human CD40 antigen, a transmembrane receptor of the tumor necrosis factor gene superfamily. CD40 is a costimulatory protein constitutively expressed by antigen presenting cells, including dendritic cells, B cells, and macrophages and on endothelial, smooth muscle cells, and fibroblasts. The binding of CD40 to CD154 (CD40L) on T helper cells activates antigen presenting cells and enhances the expression of cytokines, chemokines, matrix metalloproteinases, growth factors, and adhesion molecules. CD40 has been shown to interact with members of the TRAF family.
Additional information: Clone REA733 displays negligible binding to Fc receptors.

Alternative names

Bp50, CD40L receptor, CDW40

Technical specifications

  • Antigen: CD40
  • Clone: REA733
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Bp50, CD40L receptor, CDW40
  • Entrez Gene ID: 958
  • Molecular mass of antigen [kDa]: 28
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    rhesus monkey (
    Macaca mulatta
    )
    , baboon,
    chimpanzee (
    Pan troglodytes
    )
    ,
    squirrel monkey (
    Saimiri sciureus
    )
  • Distribution of antigen: B cells, macrophages, fibroblasts, smooth muscle
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Stamenkovic, I. et al. (1989) A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO J. 8(5): 1403-1410
    2. Sato, T. et al. (1995) A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Lett. 358(2): 113-118
    3. Chatzigeorgiou, A. et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors 35(6): 474-483
Product options: 12
for 30
tests
(1)
AUD 173.00
for 100
tests
(1)
AUD 348.00
130-111-063

CD40-PE, human

for 30
tests
(1)
AUD 126.00
130-110-946

CD40-PE, human

for 100
tests
(1)
AUD 334.00
130-111-064

CD40-APC, human

for 30
tests
(1)
AUD 165.00
130-110-947

CD40-APC, human

for 100
tests
(1)
AUD 365.00
for 30
tests
(1)
AUD 165.00
for 100
tests
(1)
AUD 365.00
for 30
tests
(1)
AUD 146.00
for 100
tests
(1)
AUD 348.00
for 30
tests
(1)
AUD 97.00
for 100
tests
(1)
AUD 284.00

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