CD337 (NKp30) antibodies, human

CD337 (NKp30) antibodies, human

Clone: REA823 | Dilution: 1:50
Clone REA823 recognizes the CD337 (NKp30) receptor, which is a 30 kDa type I membrane glycoprotein characterized by a single V-type Ig-like domain in the extracellular portion. CD337 is found almost exclusively on the surface of resting or activated natural killer (NK) cells and is a member of the natural cytotoxicity receptor (NCR) family which trigger cytotoxicity in NK cells. CD337 is directly involved in target cell recognition and lysis and is expressed by all resting or activated NK cells and by a small subset of T cells. Its expression density parallels that of CD336 (NKp44). It seems to be involved in killing of cells which are lysed independently from CD336 (NKp44) and CD335 (NKp46).
Additional information: Clone REA823 displays negligible binding to Fc receptors.

Alternative names

NCR3, 1C7, LY117, MALS, NKp30

Technical specifications

  • Antigen: CD337 (NKp30)
  • Clone: REA823
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: NCR3, 1C7, LY117, MALS, NKp30
  • Entrez Gene ID: 259197
  • Molecular mass of antigen [kDa]: 20
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, Biotin
  • Selected references

    1. Pende, D. et al. (1999) Identification and molecular characterization of Nkp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. J. Exp. Med. 190: 1505-1516
    2. Sivori, S. et al. (2000) 2B4 functions as a co-receptor in human NK cell activation. Eur. J. Immunol. 30: 787-793
    3. Moretta, A. et al. (2001) Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19: 197-223
    4. Moretta, L. and Moretta, A. (2004) Unravelling natural killer function: Triggering and inhibitory human NK receptors. EMBO J. 23: 255-259
Product options: 10
for 30
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AUD 126.00
for 100
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AUD 334.00
for 30
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AUD 165.00
for 100
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AUD 365.00
for 30
tests
(1)
AUD 165.00
for 100
tests
(1)
AUD 365.00
for 30
tests
(1)
AUD 165.00
for 100
tests
(1)
AUD 365.00
for 30
tests
(1)
AUD 97.00
for 100
tests
(1)
AUD 284.00

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