CD323 (JAM3) antibodies, human

CD323 (JAM3) antibodies, human

Clone: REA429 | Dilution: 1:11
Clone REA429 recognizes the human CD323 antigen, a single-pass type I membrane protein, which is also known as junctional adhesion molecule 3 (JAM3) or JAM-C. CD323 is a member of the junctional adhesion molecule family and plays a role in leukocyte migration and cell-cell adhesion. CD323 expression is found on endothelial cells and human platelets. It is expressed at desmosomes but not at tight junctions. CD323 is also expressed at low levels on T cells and is upregulated upon activation.
Additional information: Clone REA429 displays negligible binding to Fc receptors.

Alternative names

JAM-3, JAM-C, JAM-2

Technical specifications

  • Antigen: CD323 (JAM3)
  • Clone: REA429
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: JAM-3, JAM-C, JAM-2
  • Entrez Gene ID: 83700
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: endothelial cells, T cells, platelets
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Arrate, M. P. et al. (2001) Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor. J. Biol. Chem. 276(49): 45826-45832
    2. Cunningham, S. A. et al. (2002) JAM2 interacts with alpha4beta1. Facilitation by JAM3. J. Biol. Chem. 277(31): 27589-27592
    3. Mochida, G. H. et al. (2010) A homozygous mutation in the tight-junction protein JAM3 causes hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Am. J. Hum. Genet. 87(6): 882-889
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