CD269 (BCMA) antibodies, mouse

CD269 (BCMA) antibodies, mouse

Clone: REA550 | Dilution: 1:10
Clone REA550 recognizes the mouse CD269 antigen, which is also known as B cell maturation protein BCMA. CD269 is a member of the TNF receptor superfamily. Its binding to BLyS and APRIL activates transcription factor NF-κB and stimulates IgM production by peripheral blood B cells. A soluble form of BCMA, which inhibits the proliferative activity of APRIL
in vitr o
, decreases tumor cell proliferation in nude mice. CD269 has been detected in immune organs such as spleen, thymus, bone marrow, and heart, as well as at lower levels in kidney and lung and is preferentially expressed in mature B lymphocytes.
Additional information: Clone REA550 displays negligible binding to Fc receptors.

Alternative names

TNFRSF17, Bcm, BCMA, Tnfrsf13, Tnfrsf13a

Technical specifications

  • Antigen: CD269 (BCMA)
  • Clone: REA550
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: TNFRSF17, Bcm, BCMA, Tnfrsf13, Tnfrsf13a
  • Entrez Gene ID: 21935
  • Molecular mass of antigen [kDa]: 20
  • Distribution of antigen: B cells, lymphocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Madry, C. et al. (1998) The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily. Int. Immunol. 10(11): 1693-1702
    2. Rennert, P. et al. (2000) A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member april, inhibits tumor cell growth. J. Exp. Med. 192: 1677-1684
    3. Marsters, S. A. et al. (2000) Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr. Biol. 10(13): 785-788
Product options: 8
9 µg in 300 µL (1)
AUD 49.00
30 µg in 1 mL (1)
AUD 103.00
9 µg in 300 µL (1)
AUD 64.00
30 µg in 1 mL (1)
AUD 124.00
9 µg in 300 µL (1)
AUD 64.00
30 µg in 1 mL (1)
AUD 130.00
9 µg in 300 µL (1)
AUD 21.00
30 µg in 1 mL (1)
AUD 39.00

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