CD229 (Ly-9) antibodies, human

CD229 (Ly-9) antibodies, human

Clone: REA963 | Dilution: 1:50
Clone REA963 recognizes the human CD229 antigen, a type I transmembrane glycoprotein belonging to the CD150 subfamily of leukocyte receptors of the Ig superfamily. CD229, also known as Ly-9, has four extracellular Ig domains and a cytoplasmic domain containing two copies of the tyrosine-based motif (T-I/V-Y-x-x-V/I). Via this unique motif, CD229 interacts with SH2-binding phosphatases and the adapter molecules SAP, EAT-2, and Grb2. Expression of CD229 is found on T cells, B cells, NK cells, and thymocytes. CD229 interacts homophilically via its N-terminal V-like domain and is involved in enhancing T cell activation and Tʜ2 polarization.
Additional information: Clone REA963 displays negligible binding to Fc receptors.

Alternative names

SLAMF3, Ly9, Ly-9, hly9, mLY9

Technical specifications

  • Antigen: CD229 (Ly-9)
  • Clone: REA963
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: SLAMF3, Ly9, Ly-9, hly9, mLY9
  • Entrez Gene ID: 4063
  • Molecular mass of antigen [kDa]: 67
  • Distribution of antigen: B cells, NK cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, Biotin
  • Selected references

    1. Romero, X. et al. (2004) Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). Tissue Antigens 64(2): 132-144
    2. Romero, X. et al. (2005) CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse. J. Immunol. 174(11): 7033-7042
    3. Martín, M. et al. (2005) Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229. J. Immunol. 174: 5977-5986
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