CD218 (IL-18Rα) antibodies, human

CD218 (IL-18Rα) antibodies, human

Clone: REA1095 | Dilution: 1:50
Clone REA1095 recognizes the CD218 antigen, which is also known as interleukin-18 receptor alpha (IL-18Rα) chain. IL-18 receptor is an heterodimeric receptor complex, and composed of the IL-18Rα chain and the IL-1 receptor accessory protein-like (IL-1RacPL) or IL-18Rβ chain. CD218 represents the ligand-binding chain, whereas IL-18Rβ is suggested to assist in the formation of a high affinity complex and mediates intracellular signals. IL-18R is expressed on a variety of cells including macrophages, neutrophils, natural killer (NK) cells, endothelial, and smooth muscle cells and an upregulated expression is observed on naive T cells, T helper cell type 1 (Tʜ1) cells, and B cells, in the presence IL-12.
Additional information: Clone REA1095 displays negligible binding to Fc receptors.

Alternative names

IL18R1, CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP

Technical specifications

  • Antigen: CD218 (IL-18Rα)
  • Clone: REA1095
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: IL18R1, CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP
  • Entrez Gene ID: 8809
  • Molecular mass of antigen [kDa]: 60
  • Distribution of antigen: B cells, endothelial cells, macrophages, neutrophils, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Nakamura, S. et al. (2000) Expression and responsiveness of human interleukin-18 receptor (IL-18R) on hematopoietic cell lines. Leukemia 14(6): 1052-1059
    2. Kim, S. H. et al. (2001) Functional reconstitution and regulation of IL-18 activity by the IL-18Rβ chain. J. Immunol. 166: 148-154
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