CD207 (Langerin) antibodies, mouse

CD207 (Langerin) antibodies, mouse

Clone: REA822 | Dilution: 1:50
Clone REA822 recognizes the mouse CD207 antigen, also known as Langerin, which is a 48 kDa transmembrane type II C-type lectin containing a single carbohydrate recognition domain in its extracellular region. Langerin is specifically expressed on epidermal Langerhans cells and dermal CD103
+
dendritic cells. It displays Ca
2+
-dependent binding specificity for mannose, N-acetyl-glucosamine, and fucose and is involved in antigen recognition, uptake, and transport to the Birbeck granules, whose formation is dependent on Langerin expression. The CD207 epitope shows trypsin as well as collagenase sensitivity.
Additional information: Clone REA822 displays negligible binding to Fc receptors.

Alternative names

Langerin

Technical specifications

  • Antigen: CD207 (Langerin)
  • Clone: REA822
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Langerin
  • Entrez Gene ID: 246278
  • Molecular mass of antigen [kDa]: 38
  • Distribution of antigen: dendritic cells, Langerhans cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Valladeau, J. et al. (2002) Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues. J. Immunol. 168(2): 782-792
    2. Idoyaga, J. et al. (2008)
      Cutting edge: Langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products
      in vivo
      .
      J. Immunol. 180(6): 3647-3650
Product options: 13
30 µg in 200 µL (1)
AUD 54.00
150 µg in 1 mL (1)
AUD 229.00
30 µg in 200 µL (1)
AUD 68.00
150 µg in 1 mL (1)
AUD 264.00
30 µg in 200 µL (1)
AUD 99.00
150 µg in 1 mL (1)
AUD 301.00
30 µg in 200 µL (1)
AUD 122.00
150 µg in 1 mL (1)
AUD 346.00
30 µg in 200 µL (1)
AUD 122.00
30 µg in 200 µL (1)
AUD 130.00
30 µg in 200 µL (1)
AUD 115.00
30 µg in 200 µL (1)
AUD 39.00
150 µg in 1 mL (1)
AUD 171.00

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