CD140b antibodies, human

CD140b antibodies, human

Clone: REA363 | Dilution: 1:50
Clone REA363 recognizes the human CD140b antigen, a single-pass type I membrane protein, also known as platelet-derived growth factor receptor beta (PDGFR-β). CD140b is broadly expressed in embryonic tissue and in cells of mesodermal origin in adult tissue as fibroblasts, smooth muscle cells, glial cells, and chondrocytes. It is a tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis, and migration.
Additional information: Clone REA363 displays negligible binding to Fc receptors.

Alternative names

PDGFRB, IBGC4, IMF1, JTK12, Pdgfr, PDGFR-1

Technical specifications

  • Antigen: CD140b
  • Clone: REA363
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: PDGFRB, IBGC4, IMF1, JTK12, Pdgfr, PDGFR-1
  • Entrez Gene ID: 5159
  • Molecular mass of antigen [kDa]: 121
  • Distribution of antigen: fibroblasts, smooth muscle, microglia, chondrocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, Biotin, PE
  • Selected references

    1. Gronwald, R. G. et al. (1988) Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class. Proc. Natl. Acad. Sci. U.S.A. 85(10): 3435-3439
    2. Jin, S. et al. (2008) Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells. Circ. Res. 102(12): 1483-1491
    3. Ball, S. G. et al. (2012) Inhibition of platelet-derived growth factor receptor signaling regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency. Stem Cells 30(3): 548-560
    4. Chi, S. et al. (2016) A CRISPR-based toolbox for studying T cell signal transduction. Biomed Res Int 2016
Product options: 6
for 30
tests
(1)
AUD 165.00
for 100
tests
(1)
AUD 308.00
for 30
tests
(1)
AUD 138.00
for 100
tests
(1)
AUD 259.00
130-123-995

CD140b-PE, human

for 30
tests
(1)
AUD 165.00
130-123-772

CD140b-PE, human

for 100
tests
(1)
AUD 354.00

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