CD11c antibodies, human

CD11c antibodies, human

Clone: REA618 | Dilution: 1:50
Clone REA618 recognizes the human CD11c antigen, a 145–150 kDa type I transmembrane glycoprotein, which is also known as integrin αX or CR4. It is expressed on monocytes, macrophages, NK cells, granulocytes, myeloid dendritic cells (MDCs), and subsets of T and B cells. On myeloid dendritic cells, CD11c is highly expressed on type 1 myeloid dendritic cells (CD1c (BDCA-1)
+
CD123
low
MDC1s) and low on type 2 myeloid dendritic cells (CD1c (BDCA-1)
CD123
MDC2s). CD11c, also known as integrin integrin αX or CR4, has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.
Additional information: Clone REA618 displays negligible binding to Fc receptors.

Alternative names

95, CR4, integrin αX, ITGAX, p150

Technical specifications

  • Antigen: CD11c
  • Clone: REA618
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: 95, CR4, integrin αX, ITGAX, p150
  • Entrez Gene ID: 3687
  • Molecular mass of antigen [kDa]: 126
  • Distribution of antigen: B cells, dendritic cells, granulocytes, leukemia cells, lymphocytes, macrophages, monocytes, myeloid cells, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, Biotin, VioBlue
  • Selected references

    1. Dzionek, A. et al. (2000) BDCA-2, BDCA-3, BDCA-4: Three markers for distinct subsets of dendritic cells in human peripheral blood. J. Immunol. 165: 6037-6046
    2. Bendiss-Vermare, N. et al. (2001)
      Human thymus contains IFN-alpha-producing CD11c
      , myeloid CD11c
      +
      , and mature interdigitating dendritic cells.
      J. Clin. Invest. 107: 835-844
    3. Barclay, A. N. et al. (1997) In: The Leukocyte Antigen Facts Book, Academic Press, San Diego, CA. (2nd edition): 161-162
Product options: 15
for 30
tests
(1)
AUD 171.00
for 100
tests
(1)
AUD 344.00
130-114-113

CD11c-PE, human

for 30
tests
(1)
AUD 124.00
130-113-587

CD11c-PE, human

for 100
tests
(1)
AUD 330.00
130-114-110

CD11c-APC, human

for 30
tests
(1)
AUD 156.00
130-113-584

CD11c-APC, human

for 100
tests
(1)
AUD 348.00
for 30
tests
(1)
AUD 161.00
for 100
tests
(1)
AUD 358.00
for 30
tests
(1)
AUD 161.00
for 100
tests
(1)
AUD 358.00
for 30
tests
(1)
AUD 142.00
for 100
tests
(1)
AUD 343.00
for 30
tests
(1)
AUD 95.00
for 100
tests
(1)
AUD 278.00
for 100
tests
(1)
AUD 322.00

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