CD11b antibodies, mouse

CD11b antibodies, mouse

Clone: REA592 | Dilution: 1:50
Clone REA592 recognizes the mouse CD11b antigen (Mac-1 α; integrin αM chain), which is part of the CD11b/CD18 heterodimer (Mac-1 α, Mβ2 integrin), also known as the C3 complement receptor. It functions as a receptor for complement (C3bi), fibrinogen, or clotting factor X. CD11b is expressed on monocytes, macrophages, and microglia. To a lower extent it is expressed on granulocytes, NK cells, CD5
+
B-1 cells, and subsets of dendritic cells. Clone REA592 recognizes also the non-human primate and human CD11b antigen.
Additional information: Clone REA592 displays negligible binding to Fc receptors.

Alternative names

integrin αM, Mac-1 α, Integrin alpha-M, CR3A

Technical specifications

  • Antigen: CD11b
  • Clone: REA592
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: integrin αM, Mac-1 α, Integrin alpha-M, CR3A
  • Entrez Gene ID: 3684, 16409
  • Molecular mass of antigen [kDa]: 126
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    , human
  • Distribution of antigen: monocytes, macrophages, microglia
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Pahl, H. L. et al. (1992) Characterization of the myeloid-specific CD11b promoter. Blood 79(4): 865-870
    2. Lebson, L. et al. (2010) Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. J. Neurosci. 30(29): 9651-9658
    3. Liu, T. et al. (2014)
      Gr-1
      +
      CD11b
      +
      cells facilitate Lewis lung cancer recurrence by enhancing neovasculature after local irradiation.
      Sci. Rep. 4: 4833
Product options: 13
30 µg in 200 µL (1)
AUD 96.00
150 µg in 1 mL (1)
AUD 332.00
130-113-806

CD11b-PE, mouse

30 µg in 200 µL (1)
AUD 67.00
130-113-802

CD11b-APC, mouse

30 µg in 200 µL (1)
AUD 98.00
30 µg in 200 µL (1)
AUD 143.00
30 µg in 200 µL (1)
AUD 143.00
30 µg in 200 µL (1)
AUD 122.00
150 µg in 1 mL (1)
AUD 346.00
30 µg in 200 µL (1)
AUD 121.00
150 µg in 1 mL (1)
AUD 316.00
30 µg in 200 µL (1)
AUD 113.00
30 µg in 200 µL (1)
AUD 38.00
150 µg in 1 mL (1)
AUD 169.00

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