CD117 antibodies, human

CD117 antibodies, human

Clone: REA787 | Dilution: 1:50
Clone REA787 recognizes the human CD117 antigen, also known as c-kit or SCF receptor, which is a 145 kDa receptor tyrosine kinase that is involved in stem cell signaling, activation, and proliferation. The CD117 antigen is expressed on about 1–3% of mononuclear cells from peripheral blood mononuclear cells (PBMCs) or cord blood and on up to 10% of bone marrow cells. CD117 is further expressed on basophils, myeloid dendritic cells, TCRα/β
+
T cells, CD19
+
B cells, and CD56
+
NK cells, as well as on mast cells, melanocytes, and acute myeloid leukemia (AML) blasts. Clone REA787 recognizes a different epitope than clone AC126 and may interfere with SCF-binding. It is therefore not recommended for indirect cell isolation, but is optimal for flow cytometric analysis of cells separated with the CD117 MicroBead Kit, human.
Additional information: Clone REA787 displays negligible binding to Fc receptors.

Alternative names

c-kit, PBT, SCFR, KIT

Technical specifications

  • Antigen: CD117
  • Clone: REA787
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: c-kit, PBT, SCFR, KIT
  • Entrez Gene ID: 3815
  • Molecular mass of antigen [kDa]: 107
  • Distribution of antigen: B cells, bone marrow, brain, cancer stem cells, endothelial cells, fibroblasts, hematopoietic stem cells, kidney, leukemia cells, liver, lung, mast cells, megakaryocytes, myeloid cells, NK cells, red blood cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, VioBright 515, Biotin
  • Selected references

    1. Bühring, H. J. et al. (1991) The product of the proto-oncogene c-kit (P145c-kit) is a human bone marrow surface antigen of hematopoietic precursor cells which is expressed on a subset of acute non-lymphoblastic cells. Leukemia 5: 854-860
    2. Kubo, H. et al. (2008) Increased cardiac myocyte progenitors in failing human hearts. Circulation 118: 649-657
    3. Berglund, E. et al. (2013)
      Evidence for Ca
      2+
      -regulated ATP release in gastrointestinal stromal tumors.
      Exp. Cell Res. 319(8): 1229-1238
Product options: 14
130-111-670

CD117-PE, human

for 30
tests
(1)
AUD 126.00
130-111-592

CD117-PE, human

for 100
tests
(1)
AUD 334.00
130-111-671

CD117-APC, human

for 30
tests
(1)
AUD 165.00
130-111-593

CD117-APC, human

for 100
tests
(1)
AUD 365.00
for 30
tests
(1)
AUD 165.00
for 100
tests
(1)
AUD 365.00
for 30
tests
(1)
AUD 165.00
for 100
tests
(1)
AUD 365.00
for 30
tests
(1)
AUD 184.00
for 100
tests
(1)
AUD 348.00
for 30
tests
(1)
AUD 227.00
for 100
tests
(1)
AUD 453.00
for 30
tests
(1)
AUD 97.00
for 100
tests
(1)
AUD 284.00

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