CD116 antibodies, human

CD116 antibodies, human

Clone: REA211 | Dilution: 1:11
Clone REA211 recognizes CD116, the α subunit of GM-CSF receptor, which serves as a receptor for GM-CSF cytokine. GM-CSF is involved in innate and adaptive immune responses to infection, stimuli such as presence of LPS, and inflammatory diseases, such as asthma, rheumatoid arthritis, and multiple sclerosis. The GM-CSF receptor comprises of cytokine-specific α subunit, CD116, and βc subunit, which is a common subunit shared by interleukin-3 (IL-3) and IL-5. The human CD116 is a 378 residue glycoprotein with an extracellular N-terminal Ig-like domain, two fibronectin (FnIII) domains, and a 54 residue intracellular domain. Expression of CD116 is found on myeloid cells including monocytes, macrophages, neutrophils, eosinophils, dendritic cells, fibroblasts, endothelial cells, and myeloid leukemias.
Additional information: Clone REA211 displays negligible binding to Fc receptors.

Alternative names

CSF2RA, GM-CSF-R-α

Technical specifications

  • Antigen: CD116
  • Clone: REA211
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CSF2RA, GM-CSF-R-α
  • Distribution of antigen: macrophages, monocytes, dendritic cells, fibroblasts, endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Kared, H. et al. (2008) Role of GM-CSF in tolerance induction by mobilized hematopoietic progenitors. Blood 112: 2575-2578
    2. Matsuguchi, T. et al. (1997) The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor subunit is essential for both GM-CSF-mediated growth and differentiation. J. Biol. Chem. 272: 17450-17459
Product options: 14
for 30
tests
(1)
AUD 97.00
for 100
tests
(1)
AUD 280.00
130-101-011

CD116-PE, human

for 30
tests
(1)
AUD 124.00
130-101-008

CD116-PE, human

for 100
tests
(1)
AUD 336.00
130-100-986

CD116-APC, human

for 30
tests
(1)
AUD 163.00
130-100-984

CD116-APC, human

for 100
tests
(1)
AUD 363.00
for 30
tests
(1)
AUD 163.00
for 100
tests
(1)
AUD 363.00
for 30
tests
(1)
AUD 146.00
for 100
tests
(1)
AUD 346.00
for 30
tests
(1)
AUD 146.00
for 100
tests
(1)
AUD 346.00
for 30
tests
(1)
AUD 97.00
for 100
tests
(1)
AUD 280.00

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