Anti-Under-phospho Rb antibodies, human

Anti-Under-phospho Rb antibodies, human

Clone: REA708 | Dilution: 1:50
Clone REA708 recognizes the human Under-phospho Rb, also known as underphosphorylated Rb protein (retinoblastoma protein). The retinoblastoma protein is a nuclear phosphoprotein which acts as a tumor suppressor in normal cells. The underphosphorylated, active form of the retinoblastoma protein is present in resting or completely differentiated cells and can interact with E2F1 and represses its transcription activity, which leads to cell cycle arrest. The phosphorylated forms of retinoblastoma protein are found in proliferating cells.
Additional information: Clone REA708 displays negligible binding to Fc receptors.

Alternative names

Underphosphorylated retinoblastoma protein, Retinoblastoma-associated protein, p105-Rb, pRb, RB, pp110, Underphosphorylated RB

Technical specifications

  • Antigen: Under-phospho Rb
  • Clone: REA708
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: Underphosphorylated retinoblastoma protein, Retinoblastoma-associated protein, p105-Rb, pRb, RB, pp110, Underphosphorylated RB
  • Entrez Gene ID: 5925
  • Molecular mass of antigen [kDa]: 106
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Chellappan, S. et al. (1992) Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc. Natl. Acad. Sci. U.S.A. 89(10): 4549-4553
    2. Harbour, J. W. et al. (2000) Rb function in cell-cycle regulation and apoptosis. Nat. Cell Biol. 2(4): 65-67
    3. Ren, S. et al. (2004) Cyclin C/cdk3 promotes Rb-dependent G0 exit. Cell 117(2): 239-251
Product options: 6
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AUD 126.00
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tests
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AUD 334.00
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AUD 165.00
for 100
tests
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AUD 365.00

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