Anti-TLT-2 antibodies, human

Anti-TLT-2 antibodies, human

Clone: REA514 | Dilution: 1:11
Clone REA514 recognizes the human Trem-like transcript 2 (TLT-2) antigen, a single-pass type I membrane protein, which is also known as triggering receptor expressed on myeloid cells-like protein 2 (TREML2). TLT-2 is one of the conserved TREM family members, which is expressed on B cells, T cells, macrophages, and neutrophils. It is suggested to play an important role in the immune system, for it is not only highly expressed in inflammation, but also promotes the proliferation of T cells and the production of cytokines.
Additional information: Clone REA514 displays negligible binding to Fc receptors

Alternative names

TREML2, C6orf76, TLT2

Technical specifications

  • Antigen: TLT-2
  • Clone: REA514
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TREML2, C6orf76, TLT2
  • Entrez Gene ID: 79865
  • Molecular mass of antigen [kDa]: 33
  • Distribution of antigen: B cells, T cells, macrophages, neutrophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Allcock, R. J. et al. (2003) The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur. J. Immunol. 33(2): 567-577
    2. Hashiguchi, M. et al. (2008) Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses. Proc. Natl. Acad. Sci. U.S.A. 105(30): 10495-10500
    3. Halpert, M. M. et al. (2011) TLT2 potentiates neutrophil antibacterial activity and chemotaxis in response to G protein-coupled receptor-mediated signaling. J. Immunol. 187(5): 2346-2355
Product options: 4
for 30
tests
(1)
AUD 124.00
for 100
tests
(1)
AUD 336.00
for 30
tests
(1)
AUD 163.00
for 100
tests
(1)
AUD 363.00

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