Anti-STAT1 pY701 antibodies, human and mouse

Anti-STAT1 pY701 antibodies, human and mouse

Clone: REA159 | Dilution: 1:11
Clone REA159 recognizes the Y701 phosphorylated form (pY701) of STAT1, a member of signal transducers and activators of transcription (STAT) family. STAT family members play a critical role in activation of signaling pathways in response to the presence of various cytokines and growth factors (interferon (IFN)-α, IFN-γ, EGF, PDGF, and interleukin (IL)-6). In response to binding of IFNs to their respective receptors, STAT1, which is receptor bound, is activated by phosphorylation at the Y701 residue by Janus protein tyrosine kinases (Jaks). Activation of STAT1 is accompanied by its dissociation from the receptor and formation of homodimer and complex with STAT2 and p48 followed by translocation of the homodimer and complex to the nucleus. STAT1 is involved in positive regulation of IFN-stimulated genes, negatively regulates expression of genes for thyrotropin receptor, matrix metalloproteinase 1, 2, 13, etc. and constitutive expression of caspases 1, 2, 3, and LMP2 genes. STAT1 expression is found ubiquitously.
Additional information: Clone REA159 displays negligible binding to Fc receptors.

Alternative names

CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91

Technical specifications

  • Antigen: STAT1 pY701
  • Clone: REA159
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
  • Distribution of antigen: ubiquitous
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, VioBlue
  • Selected references

    1. Mowen, K. et al. (1998) Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1. J. Biol. Chem. 273: 30073-30076
    2. Sikorski, K. et al. (2011) STAT1-mediated signal integration between IFNγ and LPS leads to increased EC and SMC activation and monocyte adhesion. Am. J. Physiol., Cell Physiol. 300: C1337-C1344
    3. Gimeno, R. et al. (1996)
      STAT1 implication in the immune response to superantigens
      in vivo.
      J. Immunol. 156: 1378-1386
    4. ten Hoeve, J. et al. (2002) Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 16: 5662-5668
Product options: 6
for 30
tests
(1)
AUD 126.00
for 100
tests
(1)
AUD 334.00
for 30
tests
(1)
AUD 165.00
for 100
tests
(1)
AUD 365.00
for 30
tests
(1)
AUD 124.00
for 100
tests
(1)
AUD 336.00

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