Anti-Rae-1 Pan Specific antibodies, mouse

Anti-Rae-1 Pan Specific antibodies, mouse

Clone: REA723 | Dilution: 1:50
Clone REA723 recognizes the Rae-1 pan specific antigen, a surface protein and member of GPI-linked (glypiated) proteins which share partial homology with MHC class I molecules. Rae-1 was detected in early mouse embryos, especially in the head region. Rae-1 is also up-regulated on a large variety of tumor cells. Together with H-60, Rae-1 is a ligand for the murine NKG2D receptor and a potent stimulator of innate immunity. The ligand-expressing tumor cells induce potent priming of cytotoxic T cells and sensitization of NK cells
in vivo
. Clone REA723 detects Rae-1α/β/γ/δ/ε.
Additional information: Clone REA723 displays negligible binding to Fc receptors.

Alternative names

mRNA export factor, Rae1, Mrnp41

Technical specifications

  • Antigen: Rae-1 Pan Specific
  • Clone: REA723
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: mRNA export factor, Rae1, Mrnp41
  • Entrez Gene ID: 66679
  • Molecular mass of antigen [kDa]: 41
  • Distribution of antigen: T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin, FITC
  • Selected references

    1. Nomura, M. et al. (1996) Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain. J. Biol. Chem. 120(5): 987-995
    2. Diefenbach, A. et al. (2000) Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat. Immunol. 1(2): 119-126
    3. Diefenbach, A. et al. (2001) Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413(6852): 165-171
Product options: 10
30 µg in 200 µL (1)
AUD 54.00
30 µg in 200 µL (1)
AUD 70.00
150 µg in 1 mL (1)
AUD 268.00
30 µg in 200 µL (1)
AUD 101.00
150 µg in 1 mL (1)
AUD 307.00
30 µg in 200 µL (1)
AUD 124.00
30 µg in 200 µL (1)
AUD 132.00
30 µg in 200 µL (1)
AUD 117.00
30 µg in 200 µL (1)
AUD 39.00
150 µg in 1 mL (1)
AUD 173.00

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