Anti-PAX-5 (BSAP) antibodies, human and mouse

Anti-PAX-5 (BSAP) antibodies, human and mouse

Clone: REA140 | Dilution: 1:11
Clone REA140 recognizes PAX-5, which belongs to the paired box (PAX) gene family of transcription factors. PAX-5 is the only mammalian PAX transcription factor, which is expressed in hematopoietic cells. Within the hematopoietic cells, expression of PAX-5 is limited to cells of the B-lymphocyte lineage and it exerts transcriptional control of B cell commitment, development, and tumorigenesis. PAX-5 contains DNA binding conserved ‘paired’ domain, which consists of an N- and a C-terminal subdomain. Each subregion contains a homeodomain-like helix-turn-helix motif, which binds to a half-site of the PAX-5 recognition sequence. Depending upon the interaction partners, PAX-5 serves either as an activator or repressor of transcription. For instance, Groucho protein family members, by binding to a conserved octapeptide motif of PAX-5, enable PAX-5 to serve as a repressor.
Additional information: Clone REA140 displays negligible binding to Fc receptors.

Alternative names

ALL3, BSAP, EBB-1, KLP

Technical specifications

  • Antigen: PAX-5 (BSAP)
  • Clone: REA140
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: ALL3, BSAP, EBB-1, KLP
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, PerCP-Vio700
  • Selected references

    1. He, T., et al. (2011) Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity. J. Biol. Chem. 286: 14137-14145
    2. Pridans, C. et al. (2008) Identification of Pax5 target genes in early B cell differentiation. J. Immunol. 180: 1719-1728
    3. Fazio, G. et al. (2008) PAX5/TEL acts as a transcriptional repressor causing down-modulation of CD19, enhances migration to CXCL12, and confers survival advantage in pre-BI cells. Cancer Res. 68: 181-189
Product options: 8
for 30
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AUD 124.00
for 100
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AUD 336.00
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AUD 163.00
for 100
tests
(1)
AUD 363.00
for 30
tests
(1)
AUD 163.00
for 100
tests
(1)
AUD 363.00
for 30
tests
(1)
AUD 146.00
for 100
tests
(1)
AUD 346.00

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