Anti-Notch3 antibodies, human

Anti-Notch3 antibodies, human

Clone: REA1219 | Dilution: 1:50
Clone REA1219 recognizes the extracellular domain of human Notch3, one of four members of the Notch family of receptors. Upon binding its membrane-bound ligand of the Delta-like or Jagged family members, the Notch receptor undergoes two proteolytic cleavage steps eventually releasing the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, where it activates transcription within a multi-protein complex. Notch3 is expressed on various various hematopetic cells, including T cell precursors in the thymus and activated peripheral T cells. It can also be expressed on vascular smooth muscle and cells of the central nervous system. In addition, the altered expression of Notch3 by various leukemias, lymphomas and cancers has been reported.
Additional information: Clone REA1219 displays negligible binding to Fc receptors.

Alternative names

Notch 3

Technical specifications

  • Antigen: Notch3
  • Clone: REA1219
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Notch 3
  • Entrez Gene ID: 4854
  • Molecular mass of antigen [kDa]: 240
  • Distribution of antigen: hematopoietic cells, T cells, smooth muscle, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, Biotin
Product options: 10
for 30
tests
(1)
AUD 165.00
for 100
tests
(1)
AUD 308.00
for 30
tests
(1)
AUD 165.00
for 100
tests
(1)
AUD 308.00
for 30
tests
(1)
AUD 184.00
for 100
tests
(1)
AUD 336.00
for 30
tests
(1)
AUD 184.00
for 100
tests
(1)
AUD 336.00
for 30
tests
(1)
AUD 138.00
for 100
tests
(1)
AUD 259.00