Anti-MRP14 antibodies, human

Anti-MRP14 antibodies, human

Clone: REA859 | Dilution: 1:50
Clone REA859 recognizes the human MRP14 antigen, a calcium- and zinc-binding protein also known as S100A9 or calgranulin-B. MRP14 is mainly expressed in myeloid cells, e.g. MDSCs, neutrophils, and monocytes, and plays an important role in the regulation of inflammatory processes and immune response. MRP14 is involved in neutrophil chemotaxis and adhesion, and is able to increase the bactericidal activity of neutrophils.
Additional information: Clone REA859 displays negligible binding to Fc receptors.

Alternative names

S100-A9, Calgranulin-B, MRP-14, p14

Technical specifications

  • Antigen: MRP14
  • Clone: REA859
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: S100-A9, Calgranulin-B, MRP-14, p14
  • Entrez Gene ID: 6280
  • Molecular mass of antigen [kDa]: 13
  • Distribution of antigen: neutrophils, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Vio515
  • Selected references

    1. Odink, K. et al. (1987) Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis. Nature 330(6143): 80-82
    2. Rammes, A. et al. (1997) Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J. Biol. Chem. 272(14): 9496-9502
    3. Loser, K. et al. (2010)
      The toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8
      +
      T cells.
      Nat. Med. 16(6): 713-717
Product options: 8
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