Anti-MHC Class II (I-Ak) antibodies, mouse

Anti-MHC Class II (I-Ak) antibodies, mouse

Clone: REA610 | Dilution: 1:10
Clone REA610 recognizes the β chain of the mouse MHC class II alloantigen I-Ak of H-2k bearing mouse strains. It also cross-reacts with the H-2f, H-2r, and H-2s haplotypes, but reactivity to other haplotypes (i.e., b, d, p, and q) has not been observed. It also cross-reacts with splenocytes from nonobese diabetic (NOD) mice, and with lymph node cells of BN, DA, WRA, and WRC rats. MHC class II is expressed on antigen-presenting cells, such as dendritic cells, monocytes, macrophages, B cells in lymphoid and non-lymphoid tissue, thymic epithelial cells, and on subsets of hematopoietic progenitor cells in the bone marrow.
Additional information: Clone REA610 displays negligible binding to Fc receptors.

Alternative names

MHC class II IAk, Aßk, A beta K, Aalpha, H-2Aa, H2Aa, I-Aalpha, IAalpha

Technical specifications

  • Antigen: MHC Class II (I-Ak)
  • Clone: REA610
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: MHC class II IAk, Aßk, A beta K, Aalpha, H-2Aa, H2Aa, I-Aalpha, IAalpha
  • Entrez Gene ID: 14960
  • Molecular mass of antigen [kDa]: 26
  • Distribution of antigen: B cells, dendritic cells, hematopoietic stem cells, macrophages, monocytes, thymic epithelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, APC-Vio770, Biotin, VioBright FITC
  • Selected references

    1. Bhattacharya, A. et al. (1981) A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication. J. Immunol. 127(6): 2488-2495
    2. Nelson, C. A. et al. (1996) A negatively charged anchor residue promotes high affinity binding to the MHC class II molecule I-Ak. J. Immunol. 157(2): 755-762
    3. Ting, J. P. et al. (2002) Genetic control of MHC class II expression. Cell 109: 21-33
Product options: 12
9 µg in 300 µL (1)
AUD 52.00
30 µg in 1 mL (1)
AUD 101.00
9 µg in 300 µL (1)
AUD 35.00
30 µg in 1 mL (1)
AUD 70.00
9 µg in 300 µL (1)
AUD 52.00
30 µg in 1 mL (1)
AUD 101.00
9 µg in 300 µL (1)
AUD 62.00
30 µg in 1 mL (1)
AUD 124.00
9 µg in 300 µL (1)
AUD 66.00
30 µg in 1 mL (1)
AUD 132.00
9 µg in 300 µL (1)
AUD 19.00
30 µg in 1 mL (1)
AUD 39.00

Related products

2 products available