Anti-IL-12R β2 antibodies, mouse

Anti-IL-12R β2 antibodies, mouse

Clone: REA200 | Dilution: 1:10
Clone REA200 recognizes the mouse Interleukin-12 receptor subunit beta-2 (IL-12R β2) antigen, a Single-pass type I membrane protein which forms the functional high affinity IL-12 receptor together with the IL-12R β1 subunit. While the IL-12R β1 subunit is constitutively expressed, the expression of the IL-12R β2 gene is up-regulated by interferon gamma. IL-12R β2 is expressed by Th1 cells and IL-12 signaling through the IL-12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL-12R β2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules. The up-regulation of IL-12R β2 is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
Additional information: Clone REA200 displays negligible binding to Fc receptors.

Alternative names

IL12RB2, IL-12RB2, Ifnm

Technical specifications

  • Antigen: IL-12R β2
  • Clone: REA200
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: IL12RB2, IL-12RB2, Ifnm
  • Entrez Gene ID: 16162
  • Molecular mass of antigen [kDa]: 96
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Nishikomori, R. et al. (2002) Activated STAT4 has an essential role in Tʜ1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling. J. Immunol. 169(8): 4388-4398
    2. Yin, Z. et al. (2000) Dominance of IL-12 over IL-4 in gamma delta T cell differentiation leads to default production of IFN-gamma: failure to down-regulate IL-12 receptor beta 2-chain expression. J. Immunol. 164(6): 3056-3064
    3. Presky, D. H. et al. (1996) A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc. Natl. Acad. Sci. U.S.A. 93(24): 14002-14007
Product options: 10
9 µg in 300 µL (1)
AUD 33.00
30 µg in 1 mL (1)
AUD 70.00
9 µg in 300 µL (1)
AUD 49.00
30 µg in 1 mL (1)
AUD 103.00
9 µg in 300 µL (1)
AUD 64.00
30 µg in 1 mL (1)
AUD 124.00
9 µg in 300 µL (1)
AUD 64.00
30 µg in 1 mL (1)
AUD 130.00
9 µg in 300 µL (1)
AUD 21.00
30 µg in 1 mL (1)
AUD 39.00

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