Anti-β-Catenin antibodies, human and mouse

Anti-β-Catenin antibodies, human and mouse

Clone: REA480 | Dilution: 1:50
Clone REA480 recognizes the human and mouse β-catenin antigen, a 92 kDa dual function protein regulating the coordination of cell-cell adhesion and gene transcription. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. As a component of adherens junctions, β-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor adenomatous polyposis coli (APC). Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors as well as ovarian and endometrial cancer.
Additional information: Clone REA480 displays negligible binding to Fc receptors.

Alternative names

CTNNB1, CTNNB, MRD19, armadillo, CTNB1, Beta-catenin, Catnb

Technical specifications

  • Antigen: β-Catenin
  • Clone: REA480
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: CTNNB1, CTNNB, MRD19, armadillo, CTNB1, Beta-catenin, Catnb
  • Entrez Gene ID: 1499, 12387
  • Molecular mass of antigen [kDa]: 85
  • Distribution of antigen: endothelial cells, epithelial cells, keratinocytes, fibroblasts, ubiquitous, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, FITC, APC
  • Selected references

    1. Butz, S. et al. (1992) Plakoglobin and beta-catenin: distinct but closely related. Science 257(5073): 1142-1144
    2. Clevers, H. et al. (2012) Wnt/β-catenin signaling and disease. Cell 149(6): 1192-1205
    3. MacDonald, B. T. et al. (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17(1): 9-26
Product options: 6
for 30
tests
(1)
AUD 165.00
for 100
tests
(1)
AUD 308.00
for 30
tests
(1)
AUD 138.00
for 100
tests
(1)
AUD 298.00
for 30
tests
(1)
AUD 165.00
for 100
tests
(1)
AUD 308.00

Related products

4 products available