Anti-ASGPR1 antibodies, human

Anti-ASGPR1 antibodies, human

Clone: REA608 | Dilution: 1:11
Clone REA608 recognizes the human and rat asialoglycoprotein receptor 1 (ASGPR1) antigen, a single-pass type II membrane protein, also known as C-type lectin domain family 4 member H1 (CLEC4H1) or hepatic lectin H1 (HL-1). ASGPR1 is the major subunit of the asialoglycoprotein receptor (ASGPR) and is specifically expressed on the sinusoidal and basolateral hepatocellular membranes, but not on the bile canalicular membrane. It plays a role in the clearance of desialylated proteins from the serum through endocytosis and lysosomal degradation.
Additional information: Clone REA608 displays negligible binding to Fc receptors.

Alternative names

Hepatic lectin, Asialoglycoprotein receptor 1, ASGP-R 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1, ASGR1, CLEC4H1

Technical specifications

  • Antigen: ASGPR1
  • Clone: REA608
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Hepatic lectin, Asialoglycoprotein receptor 1, ASGP-R 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1, ASGR1, CLEC4H1
  • Entrez Gene ID: 432
  • Molecular mass of antigen [kDa]: 33
  • Cross-reactivity: rat
  • Distribution of antigen: liver
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
  • Selected references

    1. Yang, J. et al. (2006) Antisense oligonucleotides targeted against asialoglycoprotein receptor 1 block human hepatitis B virus replication. J. Viral Hepat. 13(3): 158-165
    2. Rigopoulou, E. I. et al. (2012) Asialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: lost and found. Autoimmun Rev 12(2): 260-269
    3. Shi, B. et al. (2013) Expression of asialoglycoprotein receptor 1 in human hepatocellular carcinoma. J. Histochem. Cytochem. 61(12): 901-909
Product options: 8
for 30
tests
(1)
AUD 173.00
for 100
tests
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AUD 348.00
for 30
tests
(1)
AUD 126.00
for 100
tests
(1)
AUD 334.00
for 30
tests
(1)
AUD 165.00
for 100
tests
(1)
AUD 365.00
for 30
tests
(1)
AUD 97.00
for 100
tests
(1)
AUD 284.00

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