StemMACS™ Y27632

StemMACS™ Y27632

StemMACS™ Y27632 is a selective small molecule inhibitor of Rho-associated kinase (ROCK).

Background information

Rho-associated kinase is found in two isoforms, ROCK I (p160ROCK, ROCKβ) and ROCK II (ROCKα), both of which are inhibited by Y27632. The inhibition is reversible and competitive with respect to ATP.

Applications

Published applications for Y27632 include:
  • Improved survival of human pluripotent stem cells after dissociation into single cells, e.g. during cell passaging or cell separation1
  • Improved survival after thawing2
  • Selected references

    1. Watanabe, K. et al. (2007) A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat. Biotechnol. 25: 681-686
    2. Li, X. et al. (2009) ROCK inhibitor improves survival of cryopreserved serum/feeder-free single human embryonic stem cells. Hum. Reprod. 24: 580-589
  • Brochures and posters

Product options: 3
130-103-922

StemMACS Y27632

2 mg
AUD 196.00
130-104-169

StemMACS Y27632

5×2 mg
AUD 773.00
2 mg
AUD 196.00

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