MACS GMP PepTivator® Mucin-1

MACS GMP PepTivator
®
Mucin-1

The MACS GMP PepTivator Mucin-1 is a peptide pool that consists mainly of 15-mer peptides. It has been developed for efficient
in vitro
stimulation and subsequent isolation of Mucin-1-specific CD4
+
and CD8
+
T cells.

Disclaimer

MACS GMP Products are for research use and
ex vivo
cell culture processing only, and are not intended for human
in vivo
applications. For regulatory status in the USA, please contact your local representative.

Background information

Mucin-1 is expressed on epithelial cells in different mucosal tissue like lung, stomach, breast or pancreas. The overexpression is associated with Adenocarcinoma, Lymphoma and Multiple Myeloma and is used as serological clinical marker of breast cancer. This makes Mucin-1 to an attractive target for anticancer immunotherapy.

Applications

The MACS GMP PepTivator Mucin-1 is used for
in vitro
stimulation of Mucin-1-effector and memory T cells. The secretion of IFN-gamma permits the enrichment of Mucin-1-specific CD4
+
and CD8
+
T cells with the use of the CliniMACS Cytokine Capture System (IFN-gamma).
Adoptive transfer of Mucin-1-specific T cells or vaccination with Mucin-1-pulsed dendritic cells may be an effective tool for the treatment of Mucin-1-expressing malignancies.

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
  • Selected references

    1. Oosterkamp et al. (1997) Comparison of MUC-1 mucin expression in epithelial and non-epithelial cancer cell lines and demonstration of a new short variant form (MUC-1/Z) Int. J. Cancer 72(1): 87-94
    2. Lacunza E. et al. (2010) MUC1 oncogene amplification correlates with protein overexpression in invasive breast carcinoma cells Cancer Genet. Cytogenet. 201(2): 102-110
    3. Lau SK et al. (2004) Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study Am. J. Clin. Pathol. 122(1): 61-69
    4. Taylor-Papadimitriou J et al. (1999) MUC1 and cancer. Biochim. Biophys. Acta 1455(2-3): 301-313
    5. Brossart P et al. (2001) The epithelial tumor antigen MUC1 is expressed in hematological malignancies and is recognized by MUC1-specific cytotoxic T-lymphocytes Cancer Res. 61(18): 6846-6850
  • Certificates

    Please follow this
    link
    to search for Certificates of Analysis (CoA) by lot number.
Product options: 1
for
stimulation of
10
9
cells
AUD 4,488.00

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