CD94 antibodies, mouse

CD94 antibodies, mouse

Clone: 18d3 | Dilution: 1:10
Clone 18d3 recognizes CD94, an approximately 70 kDa, single pass, type II transmembrane protein, which belongs to C-type lectin superfamily. CD94 associates covalently with NKG2 family members and forms disulfide bonded heterodimers. CD94-NKG2 receptors bind HLA-E, the nonclassical MHC class Ib molecule. Depending on the associated NKG2 member, CD94-NKG2 heterodimer transmits either activating or inhibitory signal. For e.g via immunoreceptor tyrosine based-inhibitory motifs (ITIMs) containing NKG2A, CD94-NKG2A heterodimers inhibit NK cell cytotoxicity. Besides NK cells, expression of CD94-NKG2 heterodimers is also shown on NK-T cells and a small percentage of CD8
+
cells in most mouse strains. DBA/2J mice do not express CD94.

Alternative names

KLRD1, Kp43

Technical specifications

  • Antigen: CD94
  • Clone: 18d3
  • Isotype: rat IgG2aκ
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: KLRD1, Kp43
  • Entrez Gene ID: 16643
  • Molecular mass of antigen [kDa]: 20,8
  • Distribution of antigen: NKT cells, T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, APC-Vio770, Biotin
  • Selected references

    1. Ho, E. L. et al. (1998) Murine Nkg2d and CD94 are clustered within the natural killer complex and are expressed independently in natural killer cells. Proc. Natl. Acad. Sci. U.S.A. 95(11): 6320-6325
    2. Vance, R. E. et al. (1997) Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur. J. Immunol. 27(12): 3236-3241
Product options: 10
130-104-037

CD94-FITC, mouse

9 µg in 300 µL (1)
EUR  24,00
130-104-005

CD94-FITC, mouse

30 µg in 1 mL (1)
EUR  35,00
130-104-038

CD94-PE, mouse

9 µg in 300 µL (1)
EUR  31,00
130-104-006

CD94-PE, mouse

30 µg in 1 mL (1)
EUR  65,00
130-104-039

CD94-APC, mouse

9 µg in 300 µL (1)
EUR  48,00
130-104-007

CD94-APC, mouse

30 µg in 1 mL (1)
EUR  65,00
9 µg in 300 µL (1)
EUR  54,00
30 µg in 1 mL (1)
EUR  85,00
9 µg in 300 µL (1)
EUR  21,00
30 µg in 1 mL (1)
EUR  35,00

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