CD88 (C5AR) antibodies, human

CD88 (C5AR) antibodies, human

Clone: S5/1 | Dilution: 1:11
Clone S5/1 recognizes the human CD88 antigen, a 43 kDa G type protein–coupled receptor with seven membrane-spanning regions which is also known as C5a anaphylatoxin chemotactic receptor 1 (C5AR). CD88 expression is originally described on neutrophils and monocyte/macrophages, but it is also found on hepatocytes, epithelial cells, endothelial cells, tissue mast cells, and human fetal astrocytes. Constitutive CD88 expression was also detected on astrocytes, microglia, and fibroblast-like cells but not by oligodendrocytes. CD88 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release, and superoxide anion production. Sulfation plays a critical role in the association of CD88 with C5a, but no significant role in the ability of CD88 to transduce a signal and mobilize calcium in response to a small peptide agonist.

Alternative names

C5AR1, C5A, C5AR, C5R1

Technical specifications

  • Antigen: CD88 (C5AR)
  • Clone: S5/1
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: C5AR1, C5A, C5AR, C5R1
  • Entrez Gene ID: 728
  • Molecular mass of antigen [kDa]: 39
  • Distribution of antigen: neutrophils, monocytes, macrophages, endothelial cells, epithelial cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Gerard, N. P. et al. (1991) The chemotactic receptor for human C5a anaphylatoxin. Nature 349(6310): 614-617
    2. Farzan, M. et al. (2001) Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor. J. Exp. Med. 193(9): 1059-1066
    3. Buck, E. et al. (2005) Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. Proc. Natl. Acad. Sci. U.S.A. 102: 2719-2724
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EUR  240,00
for 30
tests
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EUR  100,00
for 100
tests
(1)
EUR  240,00
for 30
tests
(1)
EUR  100,00
for 100
tests
(1)
EUR  240,00
for 30
tests
(1)
EUR  75,00
for 100
tests
(1)
EUR  185,00

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