CD40 antibodies – functional grade, mouse

Clone: FGK45.5
Clone FGK45.5 recognizes the mouse CD40 antigen, a 40–50 kDa glycoprotein and member of the tumor necrosis factor receptor (TNFR) superfamily. CD40 is expressed on B lymphocytes, macrophages, and dendritic cells and is an important costimulatory molecule for B cells as well as dendritic cells, monocytes, and other antigen-presenting cells (APCs). The interaction of CD40 on B cells with its ligand CD154 is involved in B cell activation and differentiation; engagement of CD40 on dendritic cells leads to maturation. Clone FGK45 can be used for blocking of CD40/CD154 interaction and for
in vitro
in vivo
activation of CD40-expressing APCs.


The CD40 pure – functional grade antibody is suited for functional assays, for example,
in vitro
in vivo
activation and maturation of antigen presenting cells, and blocking of CD40-CD154 (CD40L) binding.

Alternative names

Bp50, gp39, HIGM1, IGM, IMD3, T-BAM, TRAP, TNFRSF5, p50

Technical specifications

  • Antigen: CD40
  • Clone: FGK45.5
  • Isotype: rat IgG2a
  • Alternative names of antigen: Bp50, gp39, HIGM1, IGM, IMD3, T-BAM, TRAP, TNFRSF5, p50
  • Entrez Gene ID: 21939
  • Molecular mass of antigen [kDa]: 30
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, epithelial cells, fibroblasts, Langerhans cells, leukemia cells, lymphocytes, macrophages, mast cells, monocytes, plasma cells, platelets
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. Rolink, A. et al. (1996) The SCID but not the RAG-2 gene product is required forS mu-S epsilon heavy chain class switching. Immunity 5(4): 319-330
    2. Bonifaz, L. et al. (2002)
      Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8
      T cell tolerance.
      J. Exp. Med. 196: 1627-1638
Product options: 2
100 µg in 1 mL
EUR  125,00
1 mg in 0.5 mL
EUR  315,00

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