CD360 (IL-21R) antibodies, human

CD360 (IL-21R) antibodies, human

Clone: REA233 | Dilution: 1:11
Clone REA233 recognizes CD360, which is also known as interleukin 21 (IL-21) receptor. CD360 forms a heterodimer with the common γ subunit, which is shared by other receptors such as IL-2 and IL-15 receptor and serves as the receptor for IL-21. CD360 is a single-pass type I membrane protein and belongs to the type I cytokine receptor family. Expression of CD360 is found on variety of cells including B cells, NK cells subsets, T cells, NKT cells, dendritic cells, macrophages, and non-hematopoietic cells such as keratinocytes and fibroblasts. CD360 is composed of the cytokine-binding domain, a transmembrane domain and a large intracellular domain that contains conserved structural motifs, including the commonly described box 1 and box 2 elements, which are important for signal transduction. IL-21 mediated signaling plays vital role in mediating immune response and is involved in enhancement of adaptive T cell–immunity, antibody production, activation of natural killer cell subtypes, and opposing the suppressive effects mediated by regulatory T cells.
Additional information: Clone REA233 displays negligible binding to Fc receptors.

Alternative names

IL21R, NILR

Technical specifications

  • Antigen: CD360 (IL-21R)
  • Clone: REA233
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: IL21R, NILR
  • Distribution of antigen: B cells, dendritic cells, T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Lowe, L. et al. (2011) IL-21R is critical for the development of memory responses. J. Immunol. 186: 150
    2. Hamming, O. J. et al. (2012) Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R. J. Biol. Chem. 287: 9454-9460
Product options: 8
for 30
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(1)
EUR  90,00
for 100
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EUR  220,00
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tests
(1)
EUR  90,00
for 100
tests
(1)
EUR  220,00
for 30
tests
(1)
EUR  100,00
for 100
tests
(1)
EUR  240,00
for 30
tests
(1)
EUR  75,00
for 100
tests
(1)
EUR  185,00

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