CD283 (TLR3) antibodies, human

CD283 (TLR3) antibodies, human

Clone: TLR 3.7 | Dilution: 1:10
The monoclonal antibody TLR 3.7 reacts with CD283, also known as toll-like receptor 3 (TLR3). Toll-like receptors are a family of pattern recognition receptors that have evolved to detect components of foreign pathogens referred to as pathogenassociated molecular patterns. TLR3 is a single-pass type I membrane protein expressed exclusively in intracellular vesicles, such as the endoplasmic reticulum (ER), endosomes, lysosomes, and endolysosomes, where it recognizes microbial dsRNA. Multiple cell types are known to express TLR3 including dendritic cells, keratinocytes, and neurons. TLR3 activates via the TRIF-dependent pathway antiviral immune responses through the production of type I interferon and inflammatory cytokines, suggesting that TLR3 has an essential role in the prevention of viral infection.

Alternative names

TLR3, IIAE2

Technical specifications

  • Antigen: CD283 (TLR3)
  • Clone: TLR 3.7
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: TLR3, IIAE2
  • Entrez Gene ID: 7098
  • Molecular mass of antigen [kDa]: 101
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: dendritic cells, epithelial cells, fibroblasts, pancreas, placenta
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
  • Selected references

    1. Matsumoto, M. et al. (2002) Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem. Biophys. Res. Commun. 293: 1364-1369
    2. Rock, F. L. et al. (1998) A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. U.S.A. 95: 588-593
    3. Alexopoulou, L. et al. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413(6587): 732-738
    4. Lafon, M. et al. (2006) The innate immune facet of brain: human neurons express TLR-3 and sense vial dsRNA. J. Mol. Neurosci. 29: 185-194
    5. Visintin, A. et al. (2001) Regulation of Toll-like receptors in human monocytes and dendritic cells. J. Immunol. 166: 249
    6. de Bouteiller, O. et al. (2005) Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH. J. Biol. Chem. 280: 38133-38145
    7. Jorgenson, R. L. et al. (2005) Human endometrial epithelial cells cyclically express toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA. Hum. Immunol. 66(5): 469-482
    8. Oshiumi, H. et al. (2003) TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction. Nat. Immunol. 4: 161-167
    9. Sonali, K. and Reinhardt, T. A. (2005) Increased expression of TLR3 in lymph nodes during simian immunodeficiency virus infection: implications for inflammation and immunodeficiency. J. Immunol. 175: 5314-5323
Product options: 7
for 30
tests
(1)
EUR  75,00
for 100
tests
(1)
EUR  185,00
for 30
tests
(1)
EUR  90,00
for 100
tests
(1)
EUR  220,00
for 30
tests
(1)
EUR  90,00
for 100
tests
(1)
EUR  220,00
for 100
tests
(1)
EUR  185,00

Related products

2 products available