CD278 (ICOS) antibodies, human, mouse, rat

CD278 (ICOS) antibodies, human, mouse, rat

Clone: REA192 | Dilution: 1:11
Clone REA192 recognizes CD278 (ICOS), which belongs to the CD28 family of proteins. CD28 family members are costimulatory receptor molecules, contain single immunoglobulin V-like domain, and belong to the immunoglobulin superfamily. CD287 recognizes inducible T cell costimulator ligand (ICOSL) as ligand and its expression is induced on activated T cells. Enhanced expression of CD278 is also observed on T cells, followed by costimulation of T cells via CD28. Further expression of CD278 is found on B cells, monocytes, and dendritic cells. Crosslinking of ICOS on T cell surface in the presence of primary stimulation signal leads to T cell proliferation and differentiation. In addition, CD278 plays role in Tʜ cell differentiation, effector T cell function, and isotype class switching.
Additional information: Clone REA192 displays negligible binding to Fc receptors.

Alternative names

ICOS, AILIM, CVID1

Technical specifications

  • Antigen: CD278 (ICOS)
  • Clone: REA192
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ICOS, AILIM, CVID1
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Akbari, O. et al. (2008)
      ICOS/ICOSL interaction is required for CD4
      +
      invariant NKT cell function and homeostatic survival
      J. Immunol. 180: 5448-5456
    2. Wassink, L. et al. (2004) ICOS expression by activated human Tʜ Cells is enhanced by IL-12 and IL-23: Increased ICOS expression enhances the effector function of both Tʜ1 and Tʜ2 cells. J. Immunol. 173: 1779-1786
Product options: 18
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EUR  240,00
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tests
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EUR  100,00
for 100
tests
(1)
EUR  240,00
for 30
tests
(1)
EUR  100,00
for 100
tests
(1)
EUR  240,00
for 30
tests
(1)
EUR  100,00
for 100
tests
(1)
EUR  240,00
for 30
tests
(1)
EUR  75,00
for 100
tests
(1)
EUR  185,00

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