CD276 antibodies, human

CD276 antibodies, human

Clone: REA1094 | Dilution: 1:50
Clone REA1094 recognizes the human CD276 antigen, a type I transmembrane protein expressed at low levels in human liver, lung, bladder, testis, prostate, breast, placenta, lymphoid organs, and many human cancers. Surface expression can be induced on T cells, natural killer cells, and macrophages as well as on dendritic cells (DC) by interferon γ (IFN-γ) and on monocytes by granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4). CD276 has been shown to function as costimulatory molecule for T cell activation by inducing T cell proliferation and IFN-γ production.
Additional information: Clone REA1094 displays negligible binding to Fc receptors.

Alternative names

4Ig-B7-H3, B7-H3, B7RP-2

Technical specifications

  • Antigen: CD276
  • Clone: REA1094
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: 4Ig-B7-H3, B7-H3, B7RP-2
  • Entrez Gene ID: 80381
  • Molecular mass of antigen [kDa]: 54
  • Distribution of antigen: B cells, dendritic cells, epithelial cells, macrophages, monocytes, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Chapoval, A. I. et al. (2001) B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol. 2(3): 269-274
    2. Castriconi, R. et al. (2004) Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis. Proc. Natl. Acad. Sci. U.S.A. 101(34): 12640-12645
    3. Chen, Y. W. et al. (2008) The immunoregulatory protein human B7H3 is a tumor-associated antigen that regulates tumor cell migration and invasion. Curr. Cancer Drug Targets 8(5): 404-413
Product options: 16
for 30
tests
(1)
EUR  75,00
for 100
tests
(1)
EUR  185,00
130-118-698

CD276-PE, human

for 30
tests
(1)
EUR  90,00
130-118-570

CD276-PE, human

for 100
tests
(1)
EUR  220,00
130-118-699

CD276-APC, human

for 30
tests
(1)
EUR  90,00
130-118-571

CD276-APC, human

for 100
tests
(1)
EUR  220,00
for 30
tests
(1)
EUR  100,00
for 100
tests
(1)
EUR  240,00
for 30
tests
(1)
EUR  100,00
for 100
tests
(1)
EUR  240,00
for 30
tests
(1)
EUR  100,00
for 100
tests
(1)
EUR  240,00
for 30
tests
(1)
EUR  100,00
for 100
tests
(1)
EUR  240,00
for 30
tests
(1)
EUR  75,00
for 100
tests
(1)
EUR  185,00

Related products

3 products available