CD272 (BTLA) antibodies, mouse

CD272 (BTLA) antibodies, mouse

Clone: REA224 | Dilution: 1:10
Clone REA224 recognizes the mouse CD272 antigen, which is also known as B- and T-lymphocyte attenuator (BTLA) or B- and T-lymphocyte-associated protein. CD272, an Ig domain superfamily receptor protein with similarities to cytotoxic T-lymphocyte antigen-4 and programmed death-1, is expressed on various cell types like splenic T and B cells, macrophages, NK cells, dendritic cells as well as lymph node tissues but very weakly in somatic tissues. A polymorphic tissue distribution between several mouse strains is seen. Crosslinking CD272 with antigen receptors results in downregulation of T cell activation and attenuates production of interleukin 2. CD272 deficient mice have increased specific antibody responses and enhanced incidence and severity of autoimmune disorders.
Additional information: Clone REA224 displays negligible binding to Fc receptors.

Alternative names

BTLA, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein

Technical specifications

  • Antigen: CD272 (BTLA)
  • Clone: REA224
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: BTLA, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein
  • Entrez Gene ID: 208154
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: B cells, T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
  • Selected references

    1. Watanabe, N. et al. (2003) BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat. Immunol. 4(7): 670-679
    2. Kobayashi, Y. et al. (2013) B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells. Proc. Natl. Acad. Sci. U.S.A. 110: 5121-5126
    3. Murphy, T. L. et al. (2010) Slow down and survive: Enigmatic immunoregulation by BTLA and HVEM. Annu. Rev. Immunol. 28: 389-411
Product options: 6
9 µg in 300 µL (1)
EUR  32,00
30 µg in 1 mL (1)
EUR  67,00
9 µg in 300 µL (1)
EUR  49,00
30 µg in 1 mL (1)
EUR  67,00
9 µg in 300 µL (1)
EUR  56,00
30 µg in 1 mL (1)
EUR  88,00

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