CD271 (LNGFR) antibodies, human

Clone: ME20.4-1.H4 | Dilution: 1:50
Clone ME20.4-1.H4 recognizes the CD271 antigen, also known as low-affinity nerve growth factor receptor (LNGFR) or neurotrophin receptor (p75 NTR). CD271 belongs to the low-affinity neurotrophin receptors and the tumor necrosis factor receptor superfamily. Initially the human CD271 (LNGFR) was described to be expressed on cells of the central and peripheral nervous system, and was suggested to be involved in the development, survival, and differentiation of cells.
1
CD271 (LNGFR) is expressed on
  • Mesenchymal stem/stromal cells (MSCs)2,3,4
  • Follicular dendritic cells5
  • Mesenchymal cells involved in mesenchymal-epithelial interactions6
  • Autonomic and sensory Neurons7
  • Oligodendrocytes8
  • Astrocytes9
  • Schwann cells10,11
  • Neural crest stem cells12

Alternative names

NGFR, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR, p75NGFR, NGFR (p75)

Technical specifications

  • Antigen: CD271 (LNGFR)
  • Clone: ME20.4-1.H4
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: NGFR, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR, p75NGFR, NGFR (p75)
  • Entrez Gene ID: 4804
  • Molecular mass of antigen [kDa]: 43
  • Cross-reactivity: monkey, goat, dog, pig, sheep
  • Distribution of antigen: B cells, bone marrow, cancer stem cells, dendritic cells, mesenchymal stem cells, monocytes, neurons
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, VioBright FITC, PE, APC, VioBlue, PE-Vio770, Biotin
  • Selected references

    1. Caneva, L. et al. (1995) Immuno-electron microscopy characterization of human bone marrow stromal cells with anti-NGFR antibodies. Blood Cells Mol. Dis. 21: 73-85
    2. Quirici, N. et al. (2002) Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies. Exp. Hematol. 30: 783-791
    3. Casaccia-Bonnefil, P. et al. (1996) Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature 383: 716-719
    4. DiStefano, P. S. and Johnson, E. M. Jr. (1988) Identification of a truncated form of the nerve growth factor receptor. Proc. Natl. Acad. Sci. U.S.A. 85: 270-274
    5. Civenni, G. et al. (2011) Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth. Cancer Res. 71(8): 3098-57363109
    6. Huber, L. J. and Chao, M. V. (1995) Mesenchymal and neuronal cell expression of the p75 neurotrophin receptor gene occur by different mechanisms. Dev. Biol. 167: 227-238
    7. Chalazonitis, A. et al. (1998)
      Age-dependent differences in the effects of GDNF and NT-3 on the development of neurons and glia from neural crest-derived precursors immunoselected from the fetal rat gut: expression of GFRalpha-1
      in vitro
      and
      in vivo
      .
      Dev. Biol. 204(2): 385-406
    8. Jones, E. A. et al. (2002) Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. Arthritis Rheum. 46: 3349-3360
    9. Rudge, J. S. et al. (1994) Neurotrophic factor receptors and their signal transduction capabilities in rat astrocytes. Eur. J. Neurosci. 6: 693-705
    10. Thomson, T. M. et al. (1988) Expression of human nerve growth factor receptor on cells derived from all three germ layers. Exp. Cell Res. 174: 533-539
    11. Pezzati, P. et al. (1992) Expression of nerve growth factor receptor immunoreactivity on follicular dendritic cells from human mucosa associated lymphoid tissues. Immunology 76: 485-490
    12. Vroemen, M. and Weidner, N. (2003) Purification of Schwann cells by selection of p75 low affinity nerve growth factor receptor expressing cells from adult peripheral nerve. J. Neurosci. Methods 124: 135-143
    13. Rozemuller, H. et al. (2010) Prospective isolation of mesenchymal stem cells from multiple mammalian species using cross-reacting anti-human monoclonal antibodies. Stem Cells Dev. 19: 1911-1921
    14. Kashiba, H. et al. (1995) Coexpression of trk family members and low-affinity neurotrophin receptors in rat dorsal root ganglion neurons. Brain Res. Mol. Brain Res. 30: 158-164
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