CD267 (TACI) antibodies, mouse

CD267 (TACI) antibodies, mouse

Clone: 8F10 | Dilution: 1:10
Clone 8F10 recognizes CD267, a type III transmembrane protein receptor that binds to APRIL and BAFF and also interacts with heparan sulfate proteoglycans (HSPGs). Expression of CD267 is found on subset of T cells, marzinal zone (MZ) and, B1 B cells. A dual role of TACI has been suggested in regulating B cell activation. TACI
mice have high number of hyper-reactive B cells, indicating an inhibitory role of TACI. On the other hand, mice lacking TACI are unable to mount normal T-cell independent type 2 (TI-2) immune response and thus suggesting a positive role in promoting B cell activation.

Alternative names

Klrk1, NKG2-D

Technical specifications

  • Antigen: CD267 (TACI)
  • Clone: 8F10
  • Isotype: rat IgG2aκ
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: Klrk1, NKG2-D
  • Entrez Gene ID: 27007
  • Molecular mass of antigen [kDa]: 27
  • Distribution of antigen: T cells, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Batten, M. et al. (2004) TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. J. Immunol. 172: 812-822
    2. Yan, M. et al. (2001) Activation and accumulation of B cells in TACI-deficient mice. Nat. Immunol. 2(7): 638-643
    3. Mackay, F. et al. (2008) TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties. Cytokine Growth Factor Rev. 19(3–4): 263-276
Product options: 6
9 µg in 300 µL (1)
EUR  32,00
30 µg in 1 mL (1)
EUR  67,00
9 µg in 300 µL (1)
EUR  49,00
30 µg in 1 mL (1)
EUR  67,00
9 µg in 300 µL (1)
EUR  22,00
30 µg in 1 mL (1)
EUR  36,00

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