CD197 (CCR7) antibodies, human

CD197 (CCR7) antibodies, human

Clone: REA108
REA108 recognizes human CD197 which is a chemokine receptor with a C-C motif that mediates homing of T cells to secondary lymphoid organs via high endothelial venules (HEV) and is also known as CCR7. For example, naive T cells migrate very efficiently through lymph nodes using the adhesion molecules L-selectin, CD62L, and CCR7. Ligands for CCR7, e.g. CCL19, are expressed by the HEV of secondary lymphoid organs, by parenchymal cells within T cell zones of lymph nodes, and by endothelial cells at the openings of lymphatic vessels within peripheral tissues. Expression of CCR7 and the CD45RA isoform distinguishes three subsets of T cells: naive T cells (CCR7
+
CD45RA
+
), central memory T cells (CCR7
+
CD45RA
), and effector memory T cells (CCR7
CD45RA
).
Additional information: Clone REA108 displays negligible binding to Fc receptors.

Alternative names

CCR7, BLR-2, CC-CKR-7, CCR-7, Cdw197, CMKBR7, EBI-1

Technical specifications

  • Antigen: CD197 (CCR7)
  • Clone: REA108
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CCR7, BLR-2, CC-CKR-7, CCR-7, Cdw197, CMKBR7, EBI-1
  • Entrez Gene ID: 1236
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: B cells, dendritic cells, macrophages, NK cells, T cells, thymocytes
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. Baldan, W. et al. (2015) Efficient and reproducible generation of tumour-infiltrating lymphocytes for renal cell carcinoma. Br. J. Cancer 112(9): 1510-1518
    2. Alvarez-Fernández, C. et al. (2016) A short CD3/CD28 costimulation combined with IL-21 enhance the generation of human memory stem T cells for adoptive immunotherapy. J. Transl. Med. 14: 214
    3. Chang, Z. L. et al. (2015) Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors. J. Transl. Med. 13: 161
    4. Frascaroli, G. et al. (2018)
      Human macrophages escape inhibition of major histocompatibility complex-dependent antigen presentation by
      Cytomegalovirus
      and drive proliferation and activation of memory CD4
      +
      and CD8
      +
      T cells.
      Front Immunol 9
    5. Tilly, G. et al. (2017) IL-15 Harnesses Pro-inflammatory Function of TEMRA CD8 in Kidney-Transplant Recipients. Front Immunol 8
    6. Sallusto, F. et al. (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401: 708-712
    7. Bacher, P. et al. (2014)
      Identification of immunogenic antigens from
      Aspergillus fumigatus
      by direct multi parameter characterization of specific conventional and regulatory CD4
      +
      T cells.
      J. Immunol. 193: 3332-3343
Product options: 1
100 µg in 100 µL
EUR  144,00