CD158e (KIR3DL1) antibodies, human

CD158e (KIR3DL1) antibodies, human

Clone: REA1005 | Dilution: 1:50
Clone REA1005 recognizes the human CD158e (KIR3DL1), a member of the killer immunoglobulin-like receptor (KIR) family expressed on CD56
dim
CD16
+
natural killer (NK) cells and CD8
+
T cells. KIRs contribute to the regulation of NK cell–mediated cytotoxicity. They are monomeric receptors possessing high allelic polymorphism with either 2 or 3 Ig-like extracellular domains. According to the length of their cytoplasmic tail, KIRs can be further subdivided into inhibitory KIRs and activating KIRs (KIR2DS or KIR3DS). KIR3DL1 provides an inhibitory signal of NK cell lytic activity upon interaction with its specific ligand, HLA-Bw4.
Additional information: Clone REA1005 displays negligible binding to Fc receptors.

Alternative names

KIR3DL1, NKB1, NKB1B, p70

Technical specifications

  • Antigen: CD158e (KIR3DL1)
  • Clone: REA1005
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: KIR3DL1, NKB1, NKB1B, p70
  • Entrez Gene ID: 3811
  • Molecular mass of antigen [kDa]: 47
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Selvakumar, A. et al. (1997) Polymorphism and domain variability of human killer cell inhibitory receptors. Immunol. Rev. 155: 183-196
    2. Djeu, J. et al. (2002) A view to a kill: signals triggering cytotoxicity. Clin. Cancer Res. 8: 636-640
    3. Farag, S. S. et al. (2002) Natural killer cell receptors: new biology and insights into the graft-versus-leukaemia effect. Blood 100(6): 1935-1947
    4. Hsu, K. et al. (2002) The killer cell immunoglobin-like (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol. Rev. 190: 40-52
  • Customer reports and application notes

Product options: 22
for 30
tests
(1)
EUR  75,00
for 100
tests
(1)
EUR  185,00
for 30
tests
(1)
EUR  90,00
for 100
tests
(1)
EUR  220,00
for 30
tests
(1)
EUR  90,00
for 100
tests
(1)
EUR  220,00
for 30
tests
(1)
EUR  95,00
for 100
tests
(1)
EUR  230,00
for 30
tests
(1)
EUR  95,00
for 100
tests
(1)
EUR  230,00
for 30
tests
(1)
EUR  100,00
for 100
tests
(1)
EUR  240,00
for 30
tests
(1)
EUR  100,00
for 100
tests
(1)
EUR  240,00
for 30
tests
(1)
EUR  100,00
for 100
tests
(1)
EUR  240,00
for 30
tests
(1)
EUR  100,00
for 100
tests
(1)
EUR  240,00
for 30
tests
(1)
EUR  125,00
for 100
tests
(1)
EUR  300,00
for 30
tests
(1)
EUR  75,00
for 100
tests
(1)
EUR  185,00

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