CD137 antibodies, human

Clone: REA765 | Dilution: 1:50
Clone REA765 recognizes the human CD137 antigen, a 30 kDa glycoprotein of the tumor necrosis factor (TNF) receptor superfamily, a group of cytokines that can cause cell death (apoptosis). CD137 is mainly expressed on activated CD4
+
and CD8
+
T cells, activated B cells, and natural killer cells, but can also be found on resting monocytes and dendritic cells. As a costimulatory molecule it is involved in the activation and survival of CD4
+
or CD8
+
T cells and NK cells. CD137 has been described to be a suitable marker for antigen-specific activation of human CD8
+
T cells, as it is not expressed on resting CD8
+
T cells and its expression is reliably induced after 24 hours of stimulation.
Additional information: Clone REA765 displays negligible binding to Fc receptors.

Alternative names

CDw137, TNFRSF9, ILA, Ly-63, 4-1BB

Technical specifications

  • Antigen: CD137
  • Clone: REA765
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CDw137, TNFRSF9, ILA, Ly-63, 4-1BB
  • Entrez Gene ID: 3604
  • Molecular mass of antigen [kDa]: 25
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: B cells, dendritic cells, epithelial cells, lymphocytes, macrophages, monocytes, fibroblasts, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio615, VioBright 515, Biotin
  • Selected references

    1. Alderson, M. R. et al. (1994) Molecular and biological characterization of human 4-1BB and its ligand. Eur. J. Immunol. 24(9): 2219-2227
    2. Wolfl, M. et al. (2007)
      Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8
      +
      T cells responding to antigen without requiring knowledge of epitope specificities.
      Blood 110: 201-210
Product options: 12
for 30
tests
(1)
EUR  100,00
for 100
tests
(1)
EUR  240,00
130-110-900

CD137-PE, human

for 30
tests
(1)
EUR  90,00
130-110-763

CD137-PE, human

for 100
tests
(1)
EUR  220,00
130-110-901

CD137-APC, human

for 30
tests
(1)
EUR  90,00
130-110-764

CD137-APC, human

for 100
tests
(1)
EUR  220,00
for 30
tests
(1)
EUR  100,00
for 100
tests
(1)
EUR  240,00
for 30
tests
(1)
EUR  125,00
for 100
tests
(1)
EUR  300,00
for 30
tests
(1)
EUR  75,00
for 100
tests
(1)
EUR  185,00

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