CD103 antibodies, mouse

CD103 antibodies, mouse

Clone: 2E7 | Dilution: 1:10
Armenian hamster IgG Clone 2E7 reacts with mouse CD103, a 175 kDa large, type I transmembrane glycoprotein also known as αE integrin. CD103 associates non-covalently with integrin β7 thereby forming the heterodimeric integrin αEβ7. It mediates cell-cell contact and is involved in homing processes by binding to its ligand e-cadherin. CD103 is expressed on >90% of intestinal intraepithelial lymphocytes (IEL), epithelial T cells, and regulatory T cells. Due to its differential expression on dendritic cells from peripheral tissues, it is useful in identifying dendritic cell subsets from intestinal lamina propria, lung, and dermis.

Alternative names

ITGAE, aM290, alpha-E1, alpha-M290

Technical specifications

  • Antigen: CD103
  • Clone: 2E7
  • Isotype: hamster IgG
  • Alternative names of antigen: ITGAE, aM290, alpha-E1, alpha-M290
  • Entrez Gene ID: 16407
  • Molecular mass of antigen [kDa]: 127
  • Distribution of antigen: B cells, breast, leukemia cells, lymphocytes, pancreas, skin, small intestine, spleen, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, Biotin, FITC
  • Selected references

    1. Bogunovic, M. et al. (2009) Origin of the lamina propria dendritic cell network. Immunity 31(3): 513-525
    2. Sung, S. S. et al. (2006) A major lung CD103 alphaE-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins. J. Immunol. 176(9): 2161-2172
    3. Ginhoux, F. et al. (2007)
      Blood-derived dermal Langerin
      +
      dendritic cells survey the skin in the steady state.
      J. Exp. Med. 204(13): 3133-3146
Product options: 2
130-102-516

CD103-APC, mouse

30 µg in 1 mL (1)
EUR  65,00
30 µg in 1 mL (1)
EUR  35,00