Anti-Siglec-H antibodies, mouse

Anti-Siglec-H antibodies, mouse

Clone: 551.3D3 | Dilution: 1:10
The Anti-Siglec-H antibody reacts with the 34 kDa mouse sialic acid-binding immunoglobulin-like lectin (Siglec) H. Siglec-H is specifically expressed on mouse plasmacytoid dendritic cells
1
- a subset of CD11c
+
dendritic cells detected at low frequency in all lymphoid tissues, peripheral blood, and some non-lymphoid tissues. Binding of antibodies to Siglec-H inhibits type I interferon production, which can be induced in plasmacytoid dendritic cells by DNA and RNA viruses.
2,3

Alternative names

SIGLECH

Technical specifications

  • Antigen: Siglec-H
  • Clone: 551.3D3
  • Isotype: rat IgG1κ
  • Isotype control: Rat IgG1 – isotype control antibodies
  • Alternative names of antigen: SIGLECH
  • Entrez Gene ID: 233274
  • Molecular mass of antigen [kDa]: 37
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
  • Selected references

    1. Blasius, A. L. et al. (2006) Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12. Blood 107(6): 2474-2476
    2. Blasius, A. et al. (2004) A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha. Blood 103(11): 4201-4206
    3. Lund, J. et al. (2003) Toll-like receptor 9–mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198(3): 513-520
Product options: 6
9 µg in 300 µL (1)
EUR  24,00
30 µg in 1 mL (1)
EUR  35,00
9 µg in 300 µL (1)
EUR  31,00
30 µg in 1 mL (1)
EUR  65,00
30 µg in 1 mL (1)
EUR  65,00
30 µg in 1 mL (1)
EUR  35,00

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