Anti-Podoplanin antibodies, human

Anti-Podoplanin antibodies, human

Clone: REA446 | Dilution: 1:50
Clone REA446 recognizes the human podoplanin antigen, a 38–44 kDa mucin-type transmembrane protein which is also known as E11, GP38, OTS8, PA2.26, T1A, or aggrus. Podoplanin has a wide variety of functions including regulation of organ development, cell motility, tumorigenesis, and metastasis. It is expressed in multiple tissues during ontogeny and in adult, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs. In lymphoid organs it is present in spleen four days postnatally. In adults, expression is detected on fibroblastic reticular cells, lymphatic endothelial cells, follicular dendritic cells in lymph node and spleen, and thymic medullary epithelial cells. Tumor cells often upregulate podoplanin as they undergo epithelial-mesenchymal transition and this upregulation is correlated with increased motility and metastasis.
Additional information: Clone REA446 displays negligible binding to Fc receptors.

Alternative names

PDPN, Aggrus, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A

Technical specifications

  • Antigen: Podoplanin
  • Clone: REA446
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: PDPN, Aggrus, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A
  • Entrez Gene ID: 10630
  • Molecular mass of antigen [kDa]: 14
  • Distribution of antigen: brain, heart, kidney, lung, osteoblasts, spleen, endothelial cells, dendritic cells, lymph node, epithelial cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Herzog, B. H. et al. (2013) Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature 502(7469): 105-109
    2. Zimmer, G. et al. (1999) Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium. Biochem. J. 341(Pt 2): 277-284
    3. Astarita, J. L. et al. (2012) Expression of tumor necrosis factor receptor 2 characterizes TLR9-driven formation of interleukin-10-producing B cells. Front Immunol 12(3): 283
Product options: 2
for 30
EUR  93,00
for 100
EUR  227,00

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