Anti-Mer antibodies, mouse

Anti-Mer antibodies, mouse

Clone: REA477 | Dilution: 1:10
Clone REA477 recognizes the mouse Mer antigen, a single-pass type I membrane protein, which is also known as proto-oncogene c-Mer or receptor tyrosine kinase MerTK. Mer is a receptor tyrosine kinase of the TAM (Tyro3, Axl, MERTK) family that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1, or GAS6. It regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells. Mer is overexpressed or ectopically expressed in a wide variety of cancers, including leukemia, non-small cell lung cancer, glioblastoma, melanoma, prostate cancer, breast cancer, colon cancer, gastric cancer, pituitary adenomas, and rhabdomyosarcomas, potentially resulting in the activation of several canonical oncogenic signaling pathways. These include the mitogen-activated protein kinase and phosphoinositide 3-kinase pathways, as well as regulation of signal transducer and activator of transcription family members, migration-associated proteins including the focal adhesion kinase and myosin light chain 2, and prosurvival proteins such as survivin and Bcl-2. In neoplastic cells, these signaling events result in functional phenotypes such as decreased apoptosis, increased migration, chemoresistance, increased colony formation, and increased tumor formation in murine models. Conversely, Mer inhibition by genetic or pharmacologic means can reverse these pro-oncogenic phenotypes.
Additional information: Clone REA477 displays negligible binding to Fc receptors.

Alternative names

MerTK, Eyk, Nyk, nmf12, c-Mer

Technical specifications

  • Antigen: Mer
  • Clone: REA477
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: MerTK, Eyk, Nyk, nmf12, c-Mer
  • Entrez Gene ID: 17289
  • Molecular mass of antigen [kDa]: 108
  • Distribution of antigen: ubiquitous
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Graham, D. K. et al. (1995) Cloning and developmental expression analysis of the murine c-mer tyrosine kinase. Oncogene 10(12): 2349-2359
    2. Cook, R. S. et al. (2013) MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis. J. Clin. Invest. 123(8): 3231-3242
Product options: 6
9 µg in 300 µL (1)
EUR  32,00
30 µg in 1 mL (1)
EUR  67,00
9 µg in 300 µL (1)
EUR  49,00
30 µg in 1 mL (1)
EUR  67,00
9 µg in 300 µL (1)
EUR  22,00
30 µg in 1 mL (1)
EUR  36,00

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