Anti-DCIR antibodies, human

Anti-DCIR antibodies, human

Clone: REA329 | Dilution: 1:11
Clone REA329 recognizes the human dendritic cell immunoreceptor (DCIR) antigen, a single-pass type II membrane protein with a single carbohydrate recognition domain which is also known as C-type lectin domain family 4 member A (CLEC4A) or lectin-like immunoreceptor (LLIR). DCIR is expressed on dendritic cells (DCs), monocytes, macrophages, B lymphocytes, and granulocytes, but not detected on NK and T cells. DCIR is strongly expressed by DC derived from blood monocytes cultured with GM-CSF and IL-4. It is mostly expressed by monocyte-related rather than Langerhans cell related DC obtained from CD34
+
progenitor cells. Finally, DCIR expression is down-regulated by signals inducing DC maturation such as CD40 ligand, LPS, or TNF-α. Thus, DCIR is differentially expressed on DC depending on their origin and stage of maturation/activation.
Additional information: Clone REA329 displays negligible binding to Fc receptors.

Alternative names

CLEC4A, CD367, CLECSF6, DDB27, HDCGC13P, LLIR

Technical specifications

  • Antigen: DCIR
  • Clone: REA329
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CLEC4A, CD367, CLECSF6, DDB27, HDCGC13P, LLIR
  • Entrez Gene ID: 50856
  • Molecular mass of antigen [kDa]: 28
  • Distribution of antigen: dendritic cells, monocytes, macrophages, B cells, lymphocytes, granulocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Bates, E. E. et al. (1999) APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. J. Immunol. 163(4): 1973-1983
Product options: 12
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(1)
EUR  77,00
for 100
tests
(1)
EUR  191,00
for 30
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EUR  93,00
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EUR  227,00
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EUR  93,00
for 100
tests
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EUR  227,00
for 30
tests
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EUR  103,00
for 100
tests
(1)
EUR  247,00
for 30
tests
(1)
EUR  103,00
for 100
tests
(1)
EUR  247,00
for 30
tests
(1)
EUR  77,00
for 100
tests
(1)
EUR  191,00

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