Clone:
18d3
Type of antibody:
Primary antibodies
Isotype:
rat IgG2aκ
Applications:
FC
Alternative names:
KLRD1, Kp43

Specifications for CD94 Antibody, anti-mouse

Overview

Clone 18d3 recognizes CD94, an approximately 70 kDa, single pass, type II transmembrane protein, which belongs to C-type lectin superfamily. CD94 associates covalently with NKG2 family members and forms disulfide bonded heterodimers. CD94-NKG2 receptors bind HLA-E, the nonclassical MHC class Ib molecule. Depending on the associated NKG2 member, CD94-NKG2 heterodimer transmits either activating or inhibitory signal. For e.g via immunoreceptor tyrosine based-inhibitory motifs (ITIMs) containing NKG2A, CD94-NKG2A heterodimers inhibit NK cell cytotoxicity. Besides NK cells, expression of CD94-NKG2 heterodimers is also shown on NK-T cells and a small percentage of CD8
+
cells in most mouse strains. DBA/2J mice do not express CD94.

Alternative names

KLRD1, Kp43

Detailed product information

Technical specifications

Clone18d3
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD94
Alternative names of antigenKLRD1, Kp43
Molecular mass of antigen [kDa]20,8
Distribution of antigenNK cells, T cells, NKT cells
Entrez Gene ID16643
RRIDAB_2659637, AB_2659638, AB_2659639, AB_2659640, AB_2659641, AB_2659642, AB_2659643, AB_2659644, AB_2659645, AB_2659636

Resources for CD94 Antibody, anti-mouse

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD94 Antibody, anti-mouse

Publications

  1. Ho, E. L. et al. (1998) Murine Nkg2d and CD94 are clustered within the natural killer complex and are expressed independently in natural killer cells. Proc. Natl. Acad. Sci. U.S.A. 95(11): 6320-6325
  2. Vance, R. E. et al. (1997) Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur. J. Immunol. 27(12): 3236-3241

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