Type of antibody:
Primary antibodies
mouse IgG1κ
Alternative names:
Igα, MB-1

Extended validation for CD79a Antibody, anti-human


Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with HM47
Cells were incubated with an excess of purified unconjugated CD79a (HM47) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for CD79a Antibody, anti-human


The monoclonal antibody HM47 reacts with the cytoplamic domain of CD79a, which is also known as mb-1 and Ig α. Along with CD79b (Ig β), CD79a is associated with surface Ig (sIg) to form the B cell antigen receptor complex. CD79a is a 47 kDa glycoprotein and comprises a single extracellular immunoglobulin domain, a transmembrane domain, and a signaling intracellular domain with immunoreceptor tyrosine-based activation motif (ITAM). CD79a/CD79b heterodimer facilitates differentiation of pre–B cells from pro–B cells, surface expression of sIg, signal transduction following antigen recognition and enodocytosis of recognised antigens. Surface expression of CD79a dimishes in plasma cells, where it is mainly found as an intracellular molecule. CD79 is considered a B cell–specific marker and is often used to identify the B cell lineage of acute lymphoblastic leukemia. Recent reports however suggest expression of CD79a in T cell acute lymphoblastic leukemia. Individuals lacking CD79a have low/absent circulating pre–B cells and serum antibodies due to a block in B cell development.

Alternative names

Igα, MB-1

Detailed product information

Technical specifications

Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Type of antibodyPrimary antibodies
Specieshuman, non-human primate
chimpanzee (
Pan troglodytes
olive baboon (
Papio anubis
, mouse
Alternative names of antigenIgα, MB-1
Molecular mass of antigen [kDa]22
Distribution of antigenB cells, lymphocytes, plasma cells
Entrez Gene ID973
RRIDAB_2811633, AB_2811640, AB_2811635, AB_2659204, AB_2659205, AB_2659206, AB_2659207, AB_2811638

Resources for CD79a Antibody, anti-human


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References for CD79a Antibody, anti-human


  1. Lin, J. and Justement, L. B. (1992) The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases. J. Immunol. 149: 1548-1555
  2. Mason, D. Y. et al. (1991) The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells. J. Immunol. 147(11): 2474-2482
  3. Minegishi, Y. et al. (1999) Mutations in Igalpha (CD79a) result in a complete block in B-cell development. J. Clin. Invest. 104(8): 1115-1121
  4. Koyama, M. et al. (1997) CD79α/CD79β heterodimers are expressed on pro-B cell surfaces without associated μ heavy chain. Int. Immunol. 9: 1767-1772
  5. Lai, R. et al. (2000) Flow cytometric detection of CD79a expression in T-cell acute lymphoblastic leukemias. Am. J. Clin. Pathol. 113(6): 823-830

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